Methods for the Collection of Resource Use Data within Clinical Trials- A Systematic Review of Studies Funded by the UK Health Technology Assessment Program

Dec 1, 2010, 00:00
10.1111/j.1524-4733.2010.00788.x
https://www.valueinhealthjournal.com/article/S1098-3015(11)71817-4/fulltext
Title : Methods for the Collection of Resource Use Data within Clinical Trials- A Systematic Review of Studies Funded by the UK Health Technology Assessment Program
Citation : https://www.valueinhealthjournal.com/action/showCitFormats?pii=S1098-3015(11)71817-4&doi=10.1111/j.1524-4733.2010.00788.x
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Open access? : No
Section Order : 7

Background

The UK Health Technology Assessment (HTA) program funds trials that address issues of clinical and cost-effectiveness to meet the needs of the National Health Service (NHS). The objective of this review was to systematically assess the methods of resource use data collection and costing; and to produce a best practice guide for data capture within economic analyses alongside clinical trials.

Methods

All 100 HTA-funded primary research papers published to June 2009 were reviewed for the health economic methods employed. Data were extracted and summarized by: health technology assessed, costing perspective adopted, evidence of planning and piloting, data collection method, frequency of data collection, and sources of unit cost data.

Results

Ninety-five studies were identified as having conducted an economic analysis, of which 85 recorded patient-level resource use. The review identified important differences in how data are collected. These included: a priori evidence of analysts having identified important cost drivers; the piloting and validation of patient-completed resource use questionnaires; choice of costing perspective; and frequency of data collection. Areas of commonality included: the extensive use of routine medical records and reliance on patient recall; and the use of standard sources of unit costs.

Conclusion

Economic data collection is variable, even among a homogeneous selection of trials designed to meet the needs of a common organization (NHS). Areas for improvement have been identified, and based on our findings and related reviews and guidelines, a checklist is proposed for good practice relating to economic data collection within clinical trials.

Categories :
  • Cost-comparison, Effectiveness, Utility, Benefit Analysis
  • Economic Evaluation
  • Health Technology Assessment
  • Literature Review & Synthesis
  • Study Approaches
  • Systems & Structure
Tags :
  • clinical trials
  • cost analysis
  • economic evaluation
  • health technology assessment
Regions :
  • North America
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