Extended-Release Trospium Chloride Improves Quality of Life in Overactive Bladder

Mar 1, 2010, 00:00
10.1111/j.1524-4733.2009.00652.x
https://www.valueinhealthjournal.com/article/S1098-3015(10)60369-5/fulltext
Title : Extended-Release Trospium Chloride Improves Quality of Life in Overactive Bladder
Citation : https://www.valueinhealthjournal.com/action/showCitFormats?pii=S1098-3015(10)60369-5&doi=10.1111/j.1524-4733.2009.00652.x
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Section Order : 11

Objectives

Overactive bladder syndrome (OAB) is a urinary condition that often exerts detrimental effects on an individual's quality of life (QoL). A once-daily, extended-release (ER) formulation of the quaternary amine trospium chloride has recently been developed for the treatment of OAB. The pooled health-related QoL (HRQoL) data from two multicenter, parallel-group, double-blind Phase III studies with trospium chloride ER 60 mg were analyzed.

Methods

Subjects aged ≥18 years with urinary urgency, frequency, and an average of ≥1 urge urinary incontinence episode per day on a 3-day bladder diary were randomized (1:1) to receive once-daily trospium 60 mg ER or placebo for 12 weeks. HRQoL was assessed at baseline and at Week 12 using the King's Health Questionnaire (KHQ) and the OAB questionnaire (OAB-q).

Results

Overall, 1165 subjects were randomized (trospium ER, n = 578; placebo, n = 587). Trospium ER produced significantly greater improvements from baseline than placebo in seven of the nine KHQ domains. At Week 12, the improvement in mean OAB-q HRQoL total score (from approximately 52 at baseline) was significantly greater with trospium ER than with placebo (+25.8 vs. +20.7; P = 0.0003). Improvements from baseline were seen with trospium ER on all eight of the OAB-q symptom bother scales.

Conclusions

Once-daily trospium 60 mg ER improved the QoL of subjects with OAB, as assessed using the KHQ and the OAB-q, in two large Phase III clinical trials.

Categories :
Tags :
  • overactive bladder
  • quality of life
  • trospium chloride
  • urinary incontinence
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