Estimating a Preference-Based Single Index from the Overactive Bladder Questionnaire

Jan 1, 2009, 00:00
10.1111/j.1524-4733.2008.00413.x
https://www.valueinhealthjournal.com/article/S1098-3015(10)60688-2/fulltext
Title : Estimating a Preference-Based Single Index from the Overactive Bladder Questionnaire
Citation : https://www.valueinhealthjournal.com/action/showCitFormats?pii=S1098-3015(10)60688-2&doi=10.1111/j.1524-4733.2008.00413.x
First page :
Section Title :
Open access? : No
Section Order : 11

Objectives

The aim of the study is to estimate a preference-based single index for calculating quality-adjusted life years for patients with overactive bladder (OAB), based on a survey of the UK general population using the 5-dimensional health classification system OAB-5D, derived from the validated Overactive Bladder Questionnaire (OAB-q).

Methods

An interview valuation survey of members of public in the South Yorkshire, UK was undertaken using the time-trade-off method. Each respondent was randomly allocated to one of 14 blocks, and valued seven states each plus the “pits” state, so that a total of 99 states were valued. A number of multivariate regression models were estimated for predicting a total of 3125 health state values defined by the classification. Models were compared and selected using a set of criteria, including overall diagnosis by adjusted R-squared, the sign and significance of individual parameter estimates, the relative size of coefficients within a given dimension and predictive ability.

Results

The mean model was recommended for use in economic evaluation.

Conclusion

This will permit the cost-effectiveness of new interventions to be assessed in patients with OAB using existing and future OAB-q data sets.

Categories :
  • Methodological & Statistical Research
  • Patient-Centered Research
  • Patient-reported Outcomes & Quality of Life Outcomes
  • Specific Diseases & Conditions
  • Survey Methods
  • Urinary/Kidney Disorders
Tags :
  • condition-specific
  • health state valuation
  • OAB-q
  • TTO
Regions :
  • Western Europe
ViH Article Tags :