Economic Evaluation of a Universal Childhood Pneumococcal Conjugate Vaccination Strategy in Ireland

Sep 1, 2008, 00:00
10.1111/j.1524-4733.2008.00341.x
https://www.valueinhealthjournal.com/article/S1098-3015(10)60569-4/fulltext
Title : Economic Evaluation of a Universal Childhood Pneumococcal Conjugate Vaccination Strategy in Ireland
Citation : https://www.valueinhealthjournal.com/action/showCitFormats?pii=S1098-3015(10)60569-4&doi=10.1111/j.1524-4733.2008.00341.x
First page :
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Open access? : No
Section Order : 12

Objective

To evaluate the cost-effectiveness of implementing a universal infant 7-valent pneumococcal conjugate vaccine (PCV7) vaccination program in the Irish health-care setting from the health-care payers' perspective.

Methods

A model was constructed in MS Excel to follow a cohort of vaccinated and unvaccinated individuals from birth over a 5-year period. The reduction in events that would be associated with PCV7 vaccination and the mortality and cost resulting from these events were analyzed. In a separate submodel, the effect of herd immunity was investigated.

Results

Implementing a PCV7 vaccine program in Ireland in a birth cohort of 61,000 infants would be expected to prevent 7703 cases of pneumococcal-related infections over 5 years, resulting in costs avoided of €2.05 million increasing to €4.6 million if the effect of herd immunity was included. The baseline incremental cost-effectiveness ratio was €249,591/life years gained (LYG), which reduced to €5997/LYG when the effect of herd immunity was included.

Conclusions

A universal infant pneumococcal conjugate vaccination could be considered highly cost-effective in the Irish health-care setting from a health-care payers' perspective, if viewed in terms of the herd immunity effect. The results of this study have positive ramifications for countries in the early stages of health technology assessment.

Categories :
  • Cost/Cost of Illness/Resource Use Studies
  • Cost-comparison, Effectiveness, Utility, Benefit Analysis
  • Decision Modeling & Simulation
  • Economic Evaluation
  • Pediatrics
  • Specific Diseases & Conditions
  • Study Approaches
Tags :
  • childhood
  • cost-effectiveness
  • herd immunity
  • pneumococcal conjugate vaccination
Regions :
  • Eastern and Central Europe
  • Western Europe
ViH Article Tags :