Assessing Productivity Loss and Activity Impairment in Severe or Difficult-to-Treat Asthma

Mar 1, 2008, 00:00
10.1111/j.1524-4733.2007.00229.x
https://www.valueinhealthjournal.com/article/S1098-3015(10)60516-5/fulltext
Title : Assessing Productivity Loss and Activity Impairment in Severe or Difficult-to-Treat Asthma
Citation : https://www.valueinhealthjournal.com/action/showCitFormats?pii=S1098-3015(10)60516-5&doi=10.1111/j.1524-4733.2007.00229.x
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Open access? : No
Section Order : 13

Objectives

Asthma can be associated with substantial productivity loss and activity impairment, particularly among those with the most severe disease. We sought to assess the performance characteristics of an asthma-specific adaptation of the Work Productivity and Activity Impairment Questionnaire (WPAI:Asthma) in patients with either severe or difficult-to-treat asthma.

Methods

We analyzed 2529 subjects from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. The WPAI:Asthma was administered at baseline and at 12 months. Asthma control and quality-of-life were simultaneously assessed using the Asthma Therapy Assessment Questionnaire and Mini-Asthma Quality-of-Life Questionnaire, respectively.

Results

Severe versus mild-to-moderate asthma was associated with a greater percentage of impairment at work (28% vs. 14%), at school (32% vs. 18%), and in daily activities (41% vs. 21%). At baseline, greater asthma control problems correlated with higher levels of impairment as measured by the WPAI (work: r = 0.54, school: r = 0.37, activity: r = 0.55). Over the 12-month follow-up period, improved quality-of-life correlated with decreased levels of impairment (work: r = −0.42, school: r = −0.36, activity: r = −0.48). In multivariate analyses, greater than 10% overall work impairment at baseline predicted emergency visits (OR 2.6 [1.6, 4.0]) and hospitalization (OR 4.9 [1.8, 13.1]) at 12 months.

Conclusions

The WPAI:Asthma correlates with other self-reported asthma outcomes in the expected manner and predicts health-care utilization at 12 months when administered to patients with severe or difficult-to-treat asthma.

Categories :
  • Cost/Cost of Illness/Resource Use Studies
  • Cost-comparison, Effectiveness, Utility, Benefit Analysis
  • Economic Evaluation
  • Patient-Centered Research
  • Patient-reported Outcomes & Quality of Life Outcomes
  • Respiratory-Related Disorders
  • Specific Diseases & Conditions
  • Study Approaches
  • Surveys & Expert Panels
Tags :
  • asthma
  • impairment
  • productivity
  • work
Regions :
  • North America
ViH Article Tags :