Evaluating Health-Related Quality of Life in Cancer Clinical Trials- The National Cancer Institute of Canada Clinical Trials Group Experience

Nov 1, 2007, 00:00
10.1111/j.1524-4733.2007.00278.x
https://www.valueinhealthjournal.com/article/S1098-3015(10)60638-9/fulltext
Title : Evaluating Health-Related Quality of Life in Cancer Clinical Trials- The National Cancer Institute of Canada Clinical Trials Group Experience
Citation : https://www.valueinhealthjournal.com/action/showCitFormats?pii=S1098-3015(10)60638-9&doi=10.1111/j.1524-4733.2007.00278.x
First page :
Section Title :
Open access? : No
Section Order : 4

Introduction

The National Cancer Institute of Canada (NCIC) Clinical Trials Group (CTG) Quality of Life (QOL) Committee was initiated in 1986.

Purpose

The purpose of this review is to describe the evolution of the Committee's work and to highlight key developments such as the formulation of a policy regarding health-related quality-of-life (HRQOL) assessment, the provision of guidelines to ensure completion of HRQOL data within the protocol requirements, the rationale behind the choice of HRQOL instruments, the timing of assessments and the development of data analytic methods. These developments are illustrated with examples from CTG studies.

Recommendations

There is a lack of concordance between conventional toxicity data and HRQOL data and comparative studies designed to elucidate these differences are to be encouraged. Also, more studies are required to compare different analytic strategies and to determine how much missing data is acceptable, particularly in oncology studies where attrition is inevitable.

Categories :
  • Clinical Trials
  • Instrument Development, Validation, & Translation
  • Oncology
  • Patient-Centered Research
  • Patient-reported Outcomes & Quality of Life Outcomes
  • Specific Diseases & Conditions
  • Study Approaches
Tags :
  • assessment
  • clinical trials
  • oncology
  • QOL
  • quality of life
Regions :
  • Global
ViH Article Tags :