Estimation of Patient Preference-Based Utility Weights from the Functional Assessment of Cancer Therapy—General

Jul 1, 2007, 00:00
10.1111/j.1524-4733.2007.00181.x
https://www.valueinhealthjournal.com/article/S1098-3015(10)60612-2/fulltext
Title : Estimation of Patient Preference-Based Utility Weights from the Functional Assessment of Cancer Therapy—General
Citation : https://www.valueinhealthjournal.com/action/showCitFormats?pii=S1098-3015(10)60612-2&doi=10.1111/j.1524-4733.2007.00181.x
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Open access? : No
Section Order : 6

Objectives

The goal of this study was to estimate an algorithm to convert responses to the Functional Assessment of Cancer Therapy—General (FACT-G) to time trade-off (TTO) utilities based on utilities for current health elicited from cancer patients.

Methods

Data for 1433 cancer patients were randomly separated into construction and validation samples. Four FACT-G questions were selected for inclusion based on correlation with Eastern Clinical Oncology Group—Performance Status (ECOG-PS) scores and TTO utilities. Item response theory was used to collapse response categories. Ordinary least squares regression with the constant constrained to one was used to estimate the algorithm.

Results

The algorithm estimated mean utility for the full validation sample within three points of observed mean utility (0.805 vs. 0.832, P 0.03, P > 0.05) for most subgroups defined by ECOG-PS and Short Form-36 physical functioning scores, and responses to the FACT-G overall quality of life item. Nevertheless, the algorithm systematically overpredicted utilities for poorer health states.

Conclusion

A FACT-G-based algorithm of cancer patient utilities was developed that estimates group mean utility scores with accuracy comparable to other indirect preference-based measures of health-related quality of life. Patient-based preferences for health outcomes of cancer treatment may be useful in multiple situations, such as managing resources within cancer centers and in understanding health states preferences among cancer experienced patients before and after treatment.

Categories :
  • Health State Utilities
  • Instrument Development, Validation, & Translation
  • Methodological & Statistical Research
  • Oncology
  • Patient-Centered Research
  • PRO & Related Methods
  • Retrospective Databases: Electronic Medical and Health Records, Admin Claims
  • Specific Diseases & Conditions
  • Study Approaches
Tags :
  • cancer
  • quality of life
  • time trade-off
  • utility
Regions :
  • North America
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