OBJECTIVES: To simulate the impact of increased daily blood glucose monitoring on risk of late complications for Type-1diabetes patients. METHODS: Previous studies have shown a relationship between increased daily blood glucose monitoring (BGM) and reduced A1C levels for Type-1 diabetes patients. This analysis quantifies the reduced risk for complications and estimates the lifetime costs for complications by modeling the effects of BGM induced lower A1C levels over a lifetime. A standard Monte Carlo simulation combining published literature for risk of long-term diabetic complications with risk functions for each complication was used. Clinical outcomes were based upon following diabetic complications: cardiovascular, neuropathy, nephropathy, retinopathy, keto-and lacto acidosis and hypoglycemia. Lifetime costs for complications were calculated as the yearly costs treating the different complications (US Medicare perspective) over a 50-year period. Clinical outcomes and lifetime costs were discounted at 3%. Patient baseline data were taken from a representative cohort of newly diagnosed type-1 diabetes patients. The effect of testing BG on A1C was taken from published literature, which showed that the reduction in A1C values from baseline was 0.70% (p <0.001) by having one daily BGM. Other studies have found similar reductions. RESULTS: The difference in QALY was 0.46 years (LYG was 0.37 years) and lifetime cost was lower, due to fewer complications for the group with more frequent BGM ($54,800 vs. $60,900 per patient over time). Furthermore, clinical outcomes showed that the largest difference in reduced risk for complications was for nephropathy where the risk was reduced by more than half in the group which did more BG test. Sensitivity analyses support the validity and reliability of the results. CONCLUSIONS: This study showed the importance of BG testing on the risk of complications for Type 1 diabetes patients. The reduced risk for complications translates into less costs and thus less burden for the patients and the society.