HEALTH UTILITY OF PATIENTS WITH TYPE 2 DIABETES AND VARIOUS SINGLE AND MULTIPLE COMPLICATIONS IN CHINA- A NATIONWIDE SURVEY
Author(s)
Wang P1, Li C2
1Fudan University, Shanghai, China, 2Sanofi, Shanghai, China
OBJECTIVES: Diabetes mellitus and its complications are reported to negatively influence health-related quality-of-life (HRQOL), the magnitude of which can be quantified via the use of health utility values. However, the data on Chinese population at national level is scant. The study aimed to assess health utility of type 2 diabetes (T2D) patients with different types of complications in China. METHODS: Totally 12,583 T2D patients who were enrolled in a randomized clinical trial of a diabetes educational program from 78 hospitals nationwide were studied in this analysis. The EQ-5D-3L questionnaire was administered to each patient to assess HRQOL and calculate health utility using the Chinese EQ-5D-3L value set. Patients’ clinical and sociodemographic information were retrieved from their electronical case report form (eCRF). Multivariate regression was adopted to explore the effects of complications on health utility, controlling for sociodemographic and clinical parameters. RESULTS: The mean age of the population was 59.5 (standard deviation=11.9) years, with the female population being 47.4%. The utility scores for presence and absence of any diabetic complication were 0.915 (n=6,155) and 0.957 (n=6,428) (P<0.01), respectively. The health utility score decreased significantly for heart failure (-0.122, 95%CI: -0.169, -0.074), Angina pectoris (-0.024, 95%CI: -0.040 to -0.007), stroke (-0.078, 95%CI: -0.096 to -0.060), proteinuria (-0.012, 95%CI: -0.019 to -0.005), kidney dialysis (-0.037, 95%CI: -0.090 to -0.017), severe vision impairment or blindness (-0.029, 95%CI: -0.040 to -0.018), diabetic foot or amputation (-0.110, 95% CI: -0.142 to -0.078), and neuropathy (-0.019, 95%CI: -0.024 to -0.013); while the significant association of myocardial infarction, peripheral vascular disease and macular edema with utility score were not detected. It also revealed a negative association between numbers of complications and utility score. CONCLUSIONS: Most of diabetic complications in T2D patients were related to lower health utility scores, and the magnitude of the impact varied with the complication.
Conference/Value in Health Info
2018-11, ISPOR Europe 2018, Barcelona, Spain
Value in Health, Vol. 21, S3 (October 2018)
Code
QL2
Topic
Patient-Centered Research
Topic Subcategory
Health State Utilities
Disease
Diabetes/Endocrine/Metabolic Disorders