OBJECTIVES: Hypoglycemic episodes, symptoms presented by patients with diabetes mellitus type II (DM2), are associated with increased mortality and decreased health-related quality of life (HRQoL). However, few studies on hypoglycemia and its relationship to outcomes exist in Brazil. This study investigated the association of hypoglycemia episodes with health outcomes for Brazilian DM2 patients.   METHODS: Data are analyzed from the 2011, 2012, & 2014 Brazil National Health and Wellness Survey (NHWS), an internet-based general health survey stratified to be representative of age and gender. Among 33,082 total respondents, 1,565 reported having been diagnosed with DM2. Respondents were categorized into groups based on hypoglycemic episodes in the past three months: not experienced (n=1,100) and experienced (n=259). Those whose hypoglycemia was unknown (n=206) were excluded from analyses. Outcomes included HRQoL, work productivity loss, and healthcare resource use in the past 6 months. Generalized linear models were used to control for demographic and health characteristics. RESULTS: Recent hypoglycemia was experienced by 16.5% of DM2 respondents (age=53.47 year; 46.0% female) in Brazil. Controlling for covariates, those with recent hypoglycemia reported worse mean HRQoL for mental (43.78 vs. 47.38), physical (43.92 vs. 47.16), and health utility (0.645 vs. 0.696) scores compared with respondents who did not recently experience hypoglycemia. Respondents with recently (vs. not recently) experienced hypoglycemia also reported higher mean presenteeism (33.5% vs. 20.6%), overall work impairment (37.27% vs. 24.75%), and activity impairment (40.73% vs. 27.90%). Lastly, those with recently (vs. not recently) experienced hypoglycemia reported higher mean number of doctor visits (8.53 vs. 5.87), emergency room visits (0.92 vs. 0.65), and hospitalizations (0.53 vs. 0.26). CONCLUSIONS: Recent hypoglycemia episodes are associated with significant burden in HRQoL, healthcare resource use, work-related productivity loss and activity impairment. These results support the need for development of health strategies to improve outcomes related to DM2 in Brazil.