POTENTIAL MEDICATION TRIGGERS OF DETERIORATED RENAL FUNCTION AMONG PATIENTS WITH TYPE 2 DIABETES- USING REAL WORLD DATA

Author(s)

Smits E¹, Houben E¹, Overbeek JA¹, de Smet PA², van Herk-Sukel MP¹, Herings RM¹, Teichert M³
¹PHARMO Institute for Drug Outcomes Research, Utrecht, The Netherlands, ²Royal Dutch Pharmacists Association (KNMP), Den Haag, The Netherlands, ³Royal Dutch Pharmacists Association (KNMP), Den Haag, NV, The Netherlands

Presentation Documents

PUK24--strong-u-smits-e-u-sup-1-sup-strong-houben-e-sup-1-sup-overbeek-ja-sup-1-sup-de-smet-pa-sup-2-sup-van-herk-sukel-mp-sup-1-sup-herings-rm-sup-1-sup-teichert-m-sup-3-sup-br-sup-1-sup-pharmo-institute-for-drug-outcomes-research-utrecht- ...

OBJECTIVES:

Identification of medication risk factors for a deteriorated renal function is important to prevent chronic renal damage. The objective of this study was to identify and confirm drug exposure as potential triggers for a deteriorated renal function among type 2 diabetes mellitus (T2DM) patients using real world data (RWD).

METHODS:

A nested case-control study within a T2DM cohort was conducted using the PHARMO Database Network. Between 1999 and 2014 cases with a deteriorated renal function were matched on sex, birth year and geographic region to controls without a decline in renal function. Date of renal decline among cases was set as index date; controls were assigned the index date of their matched cases. Exposure to drugs associated with renal function based on literature and drugs for which additional monitoring of safety is mandatory according to the European Medicines Agency in the 6 months before index date was compared between cases and controls.

RESULTS:

, based on literature, were associated with deteriorated renal function: anti-inflammatory drugs (OR 1.41 (95%CI 1.28-1.55)), contrast agents (OR 2.37 (95%CI 1.81-3.10)), antibiotics (OR 2.82 (95%CI 2.58-3.09) , anti-hypertensives (OR 2.66 (95%CI 2.42-2.93)), PPI’s (OR 2.45 (95%CI 2.24-2.67)) and statins (OR 1.35 (95%CI 1.23-1.48)). Among drugs requiring additional monitoring of safety, domperidone was associated with deterioration in renal function (OR 5.09 (95%CI 3.74-6.91)).

CONCLUSIONS:

Real world data is an important source for identification and confirmation of medication risk factors for deterioration in renal function.

Conference/Value in Health Info

2017-11, ISPOR Europe 2017, Glasgow, Scotland

Value in Health, Vol. 20, No. 9 (October 2017)

Code

PUK24

Topic

Health Service Delivery & Process of Care

Topic Subcategory

Prescribing Behavior

Disease

Diabetes/Endocrine/Metabolic Disorders

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