ARE THERE DIFFERENCES IN FACT-G SCORES BETWEEN DIFFERENT TUMOUR TYPES FOR AN EU POPULATION USING REAL WORLD DATA?
Author(s)
Hallworth P1, Simpson S2, Bennett B2, Byrne K1, Rider A3, Desai T2, Cocks K4
1Adelphi Real World, Bollington, Cheshire, UK, 2Adelphi Values Ltd, Bollington, Cheshire, UK, 3Adelphi Real World, Cheshire, UK, 4Adelphi Values, Bollington, Cheshire, UK
OBJECTIVES: The main objective of this analysis was to assess FACT-G scores from an EU sample of cancer patients to test for differences between tumour types. METHODS: Data was collected through the Adelphi Real World Disease-Specific Programmes (DSPs) across breast, gastric, melanoma, non-small cell lung and prostate cancers. Data were collected between January 2015 and March 2017, resulting in a total sample of 4899 patients. Analysis included comparisons between the tumour types using minimum important differences (MIDs) of 3 points for FACT-G sub-scales and 7 points for FACT-G total score. General linear models were used to identify significant differences between tumour types while adjusting for key covariates (age, sex and ECOG status) on quality of life (QoL) within tumour type. RESULTS: The results from the linear mixed model indicate significant differences between tumour type, ECOG status, and age group for the FACT-G total score. Patients with gastric cancer reported the poorest QoL (FACT-G total score, 49.4), NSCLC (53.1), breast (53.7), melanoma (54.7) with prostate reporting the highest (56.5), based on the least squares (LS) predicted mean scores. Comparing predicted LS means based on the MID estimates, patients with gastric tumours have lower FACT-G scores than patients with prostate cancer (difference=7.1). Patients with ECOG 0 also achieved change greater than MID compared to ECOG 1-3. CONCLUSIONS: Tumour type, age and ECOG status have a significant impact on FACT-G total score. Those with gastric cancer have worst quality of life compared to other tumour types and patients in the age group 18-34 have the lowest QoL across all sub-scales. Although not significant, females tend to have a lower FACT-G total score than males. Sub-scale analysis will also be presented.
Conference/Value in Health Info
2017-11, ISPOR Europe 2017, Glasgow, Scotland
Value in Health, Vol. 20, No. 9 (October 2017)
Code
PCN243
Topic
Patient-Centered Research
Topic Subcategory
Patient-reported Outcomes & Quality of Life Outcomes
Disease
Oncology