OBJECTIVES: To examine effectiveness of the V-Go Wearable Insulin Delivery device in terms of glycemic control, insulin utilization and healthcare cost compared to multiple daily injections (MDI) of insulin therapy among individuals with type 2 diabetes mellitus (T2DM) in the United States.

METHODS: A retrospective cohort study was performed using administrative claims from the HealthCore Integrated Research Database (HIRD^®) between 07/01/2011-07/31/2017. Study cohorts included individuals with T2DM aged 21-80 years either newly initiating V-Go or using MDI for basal/bolus insulin with prior exposure to basal ± bolus or premixed insulin. Individuals with continuous enrollment and ≥1 glycosylated hemoglobin (HbA1c) laboratory result during the baseline (6 months) and follow-up periods (3-13 months) were included. V-Go and MDI users were 1:1 matched on baseline insulin exposure, HbA1c level, and other characteristics. T-tests, chi-squared tests and McNemar’s test were used to compare follow-up outcomes.

RESULTS: Matched cohorts included 118 well-balanced pairs (mean age: 56 years; mean baseline HbA1c: 9.2%). During follow-up, both cohorts experienced improvements in glycemic control relative to baseline (% with HbA1c ≤9%, pre/post: V-Go 49/69, p<0.001; MDI 50/60, p= 0.046). With similar baseline number of insulin Rx fills and diabetes-related medication costs, V-Go users had fewer insulin Rx fills (mean change from baseline: -0.8 vs. +1.8 fills, p<0.001), a lower increase in diabetes-related medication costs (mean change in 2016 USD: $341 vs. $1,628, p=0.012), and a 21% decline in insulin total daily dose (TDD) (mean change TDD in IU: -29.2 vs. +5.8, p<0.001), as compared to MDI users, during the last 6 months of follow-up.

CONCLUSIONS: This study is the first to report clinical and economic outcomes associated with V-Go use up to a one-year follow-up period. V-Go therapy represents an opportunity to improve quality measures more efficiently and less costly among a T2DM population requiring basal + bolus treatment.