OBJECTIVES : Evidence exists on demographics and costs of diabetes patients; however, data is limited on type 2 diabetes (T2DM) patients receiving a basal-bolus insulin regimen administered as multiple daily injections (> METHODS : A systematic literature review was conducted utilizing PubMed, the Cochrane library, and clinical trials.gov. Articles were included if they reported on clinical and/or economic burden of T2DM MDI patients. Articles were published after 1996, written in English. Key exclusions included: T1DM or mixed T1DM/T2DM populations (­> RESULTS : Primary searches yielded 744 unique records, 330 full text articles were screened, and 66 met inclusion criteria. Fifty eight studies were primary observational (N=22) or interventional (N=36). Patients on insulin receiving > CONCLUSIONS : The findings of the systematic literature review suggest that T2DM patients on MDI had multiple comorbidities, microvascular complications, and substantial healthcare costs.