OBJECTIVES: To calculate the variation in the drug cost involved in the treatment of depression during 2013-2015. METHODS: Standard Treatment Guidelines (STG), 4th edition were perused to understand the management of depression. Current Index of Medical Specialities (CIMS) Oct. – Jan. 2015 issue were used to capture the price of drugs. Annual cost of drug treatment and its variation was studied. RESULTS: According to STG, drugs needed for the treatment of depression includes Fluoxetine or Sertraline or Escitalopram or Venlafaxine or Mirtazapine or Imipramine or Amitryptylline. If we initiate the treatment with Fluoxetine 20mg OD, then the minimum and maximum cost of treatment was found to be Rs.986-1789 annually. A total of 81% variation was observed in its minimum and maximum cost. Likewise, if the treatment is initiated with Amitryptylline 75mg OD, then we observed a variation of 190% in its minimum and maximum cost of treatment. Similarly, 127% variation was noted for Escitalopram 10mg OD.  CONCLUSIONS: A maximum of 3 fold variation was noted in the minimum and maximum  cost of Amitryptylline. In Indian market a huge price variation exist, which is needed to  regulate in order to maintain uniformity.