Objective: To quantify the impact of disease and its treatment on patient-reported well-being, it is important to consider the patient's economic circumstances. This study explored the relationship between annual household income and health-related psychological well-being among insured, long-term (>five years) colorectal cancer (CRC) survivors with and without permanent intestinal stomas. Methods: This is a secondary analysis of data collected as part of an NCI-funded study of health-related quality of life (HRQOL) among CRC survivors, in which 681 respondents (52% response rate) completed a survey instrument that included the modified City of Hope Quality of Life (mCOH-QOL)–Ostomy questionnaire, SF-36 v2, and socio-demographic items. Of these, 588 subjects provided income data and were included in this analysis. The mCOH-QOL–Ostomy is based on a four-dimension model of HRQOL (physical, psychological, social, and spiritual well-being). For this analysis, the dependent variable was the psychological well-being (PWB) score. Hierarchical linear regression was used to explore the unique contribution of income to the total variance of PWB over and above the model that included the following independent variables: self-reported physical health (SF-36v2 PCS), co-morbidity (Charlson-Deyo), age, sex, race/ethnicity, education, partnered status, and presence of an ostomy. Results: After accounting for the proportion of variance in PWB explained by the other independent variables, the additional variance explained by income was significant (R2 increased from 0.228 to 0.250; p=0.006). When compared to those in the highest household income category (>$100,000), subjects in the lowest income category (