OBJECTIVES: To assess the cost of the basic course of pharmacotherapy of arterial hypertension (AH) of inhibitors-ACE, direct costs associated with the correction of side effects (SE), developing on the background of their application with further pharmacoeconomics evaluation of inhibitors-ACE METHODS: Cost analysis, modeling. A consideration of the basic price of therapy trade names (TN) inhibitors-ACE INN: enalapril, lisinopril and the calculation of direct costs associated with correction of SE in patients diagnosed with stage II AH. Medical patients' route, the cost structure were modeled by questioning physicians, cardiologists of Institute of Gerontology, Clinical Hospital ¹ 55, Moscow. The study takes into account the cost: symptomatic therapy, specialist consultations, emergency care, hospital bed-days, laboratory and instrumental manipulations. Data registered in RF TN obtained from the site www.regmed.ru, information about prices - www.medlux.ru, www.cardioweb.ru. We took into account recommendations of standards of care for patients with AH, developed by Health Ministry of Russia. The cost of the basic course of pharmacotherapy and PE are estimated at 30-day time period for 1 patient. Average daily dose the drugs accounted for enalapril - 5 mg / day, lisinopril - 10 mg / day. RESULTS: The development of side effects (cough, arterial hypotension, allergies, headache, etc.) was the cause of drug withdrawal enalapril in 5.3% of patients, lisinopril at 3.8% of patients. The study calculated the cost of courses were the main pharmacotherapy TN lisinopril and enalapril, ranging from 30 to 245 Rubles, corrective therapy - from 284 to 583 Rubles. In the economic evaluation of SE was the least expensive scheme with drug enalapril, which is more advantageous from an economic position. CONCLUSIONS: The economic analysis of side effects developing on the background of the basic course of pharmacotherapy, is relevant assessment to improve the quality and credibility of pharmacoeconomics studies of drugs.