Presentation (CTI)

OBJECTIVES: Passively collected wearable data offer the potential to augment patient-reported outcomes in IBD with continuous, objective physiological signals. We assessed whether four wearable metrics - step count, sleep duration, resting heart rate (HR), and heartrate variability (HRV) correlate with validated PROMs in a real-world IBD digital cohort, with the aim of evaluating their utility as objective correlates of self-reported disease control.
METHODS: Retrospective cross-sectional analysis of consented users of the Ampersand MyIBD app with co-occurring wearable and PROM entries. The data used for analysis contained only days on which both a wearable metric value and a PROM score were recorded for the same user. Associations between each wearable metric and four PROMs -the IBD Control Symptoms Questionnaire, IBD DISK, Harvey-Bradshaw Index (HBI), and Simple Clinical Colitis Activity Index (SCCAI) were assessed using Spearman rank correlation.
RESULTS: Step count demonstrated statistically significant associations with IBD Control (ρ= 0.23, 95% CI 0.14-0.33, n=369, 127 users) and SCCAI (ρ = −0.26, 95% CI −0.40 to −0.11, n=165, 76 users), indicating that higher daily step counts correlate with better self-reported disease control. Resting HR showed significant inverse associations with IBD Control (ρ =−0.23, 95% CI −0.39 to −0.06, n=129, 39 users) and SCCAI (ρ = 0.46, 95% CI 0.19-0.66, n=46, 20 users), consistent with elevated resting HR as a correlate of worse symptom burden. Sleep duration was significantly associated with SCCAI only (ρ = 0.39, 95% CI0.16-0.58, n=63, 29 users). HRV showed no statistically significant associations with any PROM.
CONCLUSIONS: Step count and resting HR demonstrated consistent, statistically significant associations with self-reported disease control in IBD, while HRV and sleep showed more limited signal. Findings are constrained by modest sample sizes. Nevertheless, these results support the potential of passively collected wearable data as complementary objective correlates of patient-reported IBD disease activity, warranting prospective validation in larger cohorts.