Real-World Study of High-Risk Non-Muscle Invasive Bladder Cancer From Three Public Institutions in Mexico: Clinical Profile and Staging Patterns
Author(s)
Ricardo Castillejos-Molina, phD1, Anna Scavuzzo, md2, Ivan Bravo, md3, Miguel Angel Jimenez Rios, md2, Miguel Angel Jimenez Davila, md2, Jose Gadu Campos Salcedo, md3, Brenda Suaste Carmona, md3, Claudia C. Beltran, MSc, MD4, Lucia Flores-García, md5, Victoria Castillo, md6, Gaby Lugo, phD7, Francisco Tomas Rodriguez Covarrubias, phD8;
1Instituto Nacional de Nutrición Y ciencias Médicas Salvador Zubirán, Urology, CDMX, Mexico, 2INCAN, CDMX, Mexico, 3sedena, CDMX, Mexico, 4MSD, Colombia, Colombia, 5MSD, MEXICO, Mexico, 6TIS, MEXICO, Mexico, 7MSD, MD, Cdmx, Mexico, 8INNSZ, CDMX, Mexico
1Instituto Nacional de Nutrición Y ciencias Médicas Salvador Zubirán, Urology, CDMX, Mexico, 2INCAN, CDMX, Mexico, 3sedena, CDMX, Mexico, 4MSD, Colombia, Colombia, 5MSD, MEXICO, Mexico, 6TIS, MEXICO, Mexico, 7MSD, MD, Cdmx, Mexico, 8INNSZ, CDMX, Mexico
Presentation Documents
OBJECTIVES: High-risk non-muscle invasive bladder cancer (NMIBC) has high recurrence rates, with intravesical BCG shortages in Mexico potentially impacting treatment. This study was aimed to describe the clinical and histopathological characteristics of NMIBC and their treatment patterns in real-world settings from three public Mexican Institutions , focusing on histopathological features, clinical patterns, patient journeys (time to get diagnosed and start treatment), and types of treatment. Exploratory objectives focused on follow-up practices, recurrence rates, recurrence profiles, and patient demographics.
METHODS: This retrospective, observational study analyzed structured secondary data from three tertiary care hospitals in Mexico City (Hospital Central Militar, INCMNSZ, INCan). Patients diagnosed with high-risk NMIBC between 2010 and 2020 were included based on predefined clinical and histopathological criteria, such as carcinoma in situ, Tis, T1 stages, tumors >3 cm, or multifocal tumors with urothelial histology (>50%). Exclusion criteria included follow-up <6 months, concurrent malignancies, prior treatments, or small cell/neuroendocrine histology. This phase of the study presents only demographic and disease staging data
RESULTS: A total of 223 patients were analyzed, with a mean age of 65 years (range: 30-93); 75% were male (male-to-female ratio 3:1). Patients had an average weight of 71.64 kg (range: 43-125), a mean height of 1.65 m (range: 1.40-1.87), and a BMI of 26.29 kg/m² (range: 16-46.11). Smoking was reported in 57% of patients, and 83.4% of tumors were low-grade. 75% of patients were diagnosed as T1, 24% as Ta, and only 1% with carcinoma in situ. Most tumors (74.4%) were ≤3 cm, and 65.5% were solitary. Lymphovascular invasion occurred in 2.24%, and papillary tumors were the most common histological subtype (34.5%).
CONCLUSIONS: The predominance of advanced-stage diagnoses and modifiable risk factors highlights the need for early detection strategies and tailored interventions to address modifiable risk factors and improve outcomes for NMIBC patients in Mexico.
METHODS: This retrospective, observational study analyzed structured secondary data from three tertiary care hospitals in Mexico City (Hospital Central Militar, INCMNSZ, INCan). Patients diagnosed with high-risk NMIBC between 2010 and 2020 were included based on predefined clinical and histopathological criteria, such as carcinoma in situ, Tis, T1 stages, tumors >3 cm, or multifocal tumors with urothelial histology (>50%). Exclusion criteria included follow-up <6 months, concurrent malignancies, prior treatments, or small cell/neuroendocrine histology. This phase of the study presents only demographic and disease staging data
RESULTS: A total of 223 patients were analyzed, with a mean age of 65 years (range: 30-93); 75% were male (male-to-female ratio 3:1). Patients had an average weight of 71.64 kg (range: 43-125), a mean height of 1.65 m (range: 1.40-1.87), and a BMI of 26.29 kg/m² (range: 16-46.11). Smoking was reported in 57% of patients, and 83.4% of tumors were low-grade. 75% of patients were diagnosed as T1, 24% as Ta, and only 1% with carcinoma in situ. Most tumors (74.4%) were ≤3 cm, and 65.5% were solitary. Lymphovascular invasion occurred in 2.24%, and papillary tumors were the most common histological subtype (34.5%).
CONCLUSIONS: The predominance of advanced-stage diagnoses and modifiable risk factors highlights the need for early detection strategies and tailored interventions to address modifiable risk factors and improve outcomes for NMIBC patients in Mexico.
Conference/Value in Health Info
2025-05, ISPOR 2025, Montréal, Quebec, CA
Value in Health, Volume 28, Issue S1
Code
CO139
Topic
Clinical Outcomes
Topic Subcategory
Clinician Reported Outcomes
Disease
SDC: Oncology, SDC: Urinary/Kidney Disorders