* Short courses are presented in Spanish unless otherwise indicated. See short course descriptions below for full details.
8:00 – 17:00
ALL DAY COURSE
INTRODUCTION TO PHARMACOECONOMICS(Presented in Spanish) Room: Don Diego 1 Faculty: Diego Rosselli, MD Neurologist, MEd (Harvard), MHP (London School of Economics),Associate Professor of Health Economics, Javeriana Papal University, Bogotá, Colombia; Adolfo Rubinstein, MD, MSc, PhD, President, Institute for Clinical Effectiveness and Health Policy (IECS) & Director of the Master´s Program in Clinical Effectiveness, Faculty of Medicine, University of Buenos Aires Buenos Aires, Argentina
Course Description: This course is designed to teach clinicians and new researchers how to incorporate pharmacoeconomics into study design and data analysis. Participants will learn how to collect and calculate the costs of different health care or health care economic evaluation alternative treatments, determine the economic impact of clinical outcomes, and how to identify, track and assign costs to different types of health care resources used. The development of economic protocols and data collection sheets will be discussed. Different pharmacoeconomic models and techniques will be demonstrated as well as case studies. These include cost-minimization, cost-of-illness, cost-effectiveness, cost-benefit, and cost-utility analysis. Decision analysis, sensitivity analysis, and discounting, will all be demonstrated and practiced. Participants will also learn to compare and evaluate interventions such as drugs, devices and clinical services. Level: Introductory.This course is suitable for those with little or no experience with pharmacoeconomics.
8:00 – 12:00
INTRODUCTION TO MODELING (Presented in Spanish)
Room: Don Diego 2 Faculty: Federico Augustovski, MD, MSc, Director, Health Economic Evaluation and Technology Assessment, IECS (Institute for Clinical Effectiveness and Health Policy) & Staff Physician, Family and Community Medicine Division, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Pablo Anaya, MHA, HE&OR Manager, GlaxoSmithKline México, Bosque Real, Edo. de Méx., México
Course Description: This course includes a review of Markov models, discrete event models, and other modeling techniques and their appropriate applications, including a review of the ISPOR Principles of Good Practice for Decision Analytic Modeling in Health Care Evaluations. Using a series of related examples, the course will carefully review the practical steps involved in developing and using these kinds of models. Examples will be presented using predominantly Microsoft Excel, supplemented with add on simulation software. This course will cover the practical steps involved in the selection and modeling of data inputs and practical aspects related to the determination of when, why and how to handle stochastic (i.e., first order Monte Carlo Simulations) and probabilistic uncertainty (i.e., second order Monte Carlo Simulations). Issues related to the selection of model input parameters and their distributions for use in probabilistic sensitivity analyses will be considered. Participants will learn the steps required in conducting, analyzing, interpreting, and presenting results from probabilistic sensitivity analyses (e.g. using analyses of the cost-effectiveness plane, the "ellipses", and acceptability curves). Level: Introductory. This course requires a familiarity with decision analysis.
HEALTH CARE & REIMBURSEMENT SYSTEMS IN LATIN AMERICA(Presented in Spanish)
Room: Don Diego 3 Faculty: Leonardo Cubillos, MD, MPH, Health Systems Practice, World Bank Institute, Washington, DC, USA; Diego Guarín, MD, MPH, MA, Director, Market Access Latin America, Merck Sharp & Dohme, Mexico City, Mexico; Alarico Rodríguez de Leon, MD, Assistant Director of Medical Technologies, Uruguayan National Agency for Highly Specialized Medical Procedures, Montevideo, Uruguay; Henry Maquera Colque, MBA, Executive Secretary, Solidarity Health Fund of Peru (FISSAL), Lima, Peru; Giota Panopoulou, PhD, Consultant, Finance Division, Mexican Institute of Social Security, Mexico City, Mexico
Course Description: This session will first discuss the current health care systems in the main Latin American countries, discussing research implementation and its linkage with regional priorities. The faculty will then describe the reimbursement legislation, processes and organizations within these countries as well as the role of the pharmaceutical and/or medical device manufacturer. This course will then focus on providing participants with an understanding of the various procedures employed by Latin American health authorities to regulate market access based upon the appraisal of the clinical and in some countries economic value of new medical technologies. Formulary submission guidelines set analytical and evidentiary standards which drug manufacturers and others are required to meet in making a case for their product. Faculty will discuss evidentiary standards in formulary submissions. Level: Introductory.
H. Maquera Colque
INTRODUCTION TO QUALITY OF LIFE / PATIENT-REPORTED OUTCOMES (Presented in Spanish)
Room: Don Genaro
Faculty:Yajaira Bastardo, PhD, Administrative Director and Professor, School of Pharmacy, Central University of Venezuela, Caracas, Venezuela; Nelson Alvis Guzmán, PhD, MD, MPH, Professor & Researcher, Faculty of Economic Sciences & Director, Health Economics Research Group, University of Cartagena, Cartagena, Colombia
Course Description: Conceptual, methodological, and practical methods for measuring quality of life, health status and other types of health outcomes will be presented. Theoretical frameworks, reliability, validity, responsiveness, methods of administration, respondent and administrative burdens, and issues of analysis and interpretation will be discussed using examples drawn from specific quality-of-life instruments and their applications. A model of selecting appropriate instruments from the many existing generic and disease-specific instruments will be presented. Level: Introductory. This is an introductory course intended for those with little experience with these methodologies.
N. Alvis Guzman
INTRODUCTION TO META-ANALYSIS AND SYSTEMATIC LITERATURE REVIEW (Presented in Spanish)
Room: Don Americo Faculty: Agustín Ciapponi, MD, Coordinator, Argentine Cochrane Centre IECS (Institute for Clinical Effectiveness and Health Policy), Iberoamerican Cochrane Network, and Family and Community Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Sebastián García Martí, MD, MSc, Health Technology Assessment & Economic Evaluation, IECS, Buenos Aires, Argentina
Course Description: Systematic literature review and meta-analytic methods to assess the quality of evidence for health care interventions will be discussed. Statistical approaches to pooling results from several studies and application of meta-analysis in pharmacoeconomics studies and health care decision-making will be presented. Level: Introductory.This course is designed for individuals with little experience with meta-analysis
S. García Martí
BUDGET IMPACT ANALYSIS(Presented with simultaneous English-Spanish interpretation) Room: Don Diego 4 Faculty: C. Daniel Mullins, PhD, Professor and Chair, Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, Baltimore, MD, USA; Ariadna Juárez García, PhD, MSc, HEOR Manager, Health Economics, Bristol-Myers Squibb, Mexico City, Mexico
Course Description: This course will describe methods to determine the costs associated with a health condition and the budget impact of new technologies for that condition. The course will present incidence- and prevalence-based costing strategies. Treatment algorithms and event-based approaches will be demonstrated for disease-specific costs from different decision-maker perspectives. Both static and dynamic methods for estimating the budget impact of adding a new drug to a health plan formulary will be presented. Issues related to imputing missing data will also be discussed. Level: Intermediate. This course is designed for those with some experience with pharmacoeconomic analysis.
A. Juárez García
13:00 – 17:00
APPLIED MODELING (Presented in Spanish) Room: Don Diego 2 Faculty: Federico Augustovski, MD, MSc, Director, Health Economic Evaluation and Technology Assessment, IECS (Institute for Clinical Effectiveness and Health Policy) & Staff Physician, Family and Community Medicine Division, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Prof. Andrés Pichon-Riviere, MD, MSc, PhD, Executive Director, IECS, and Adjunct Professor, School of Public Health, Department of Medicine, University of Buenos Aires, Buenos Aires, Argentina; Sebastián García Martí, MD, MSc, Health Technology Assessment & Economic Evaluation, IECS, Buenos Aires, Argentina
Course Description: This course is a hands-on introduction to the use of software in the creation and analysis of cost-effectiveness decision models. The basics of cost-effectiveness decision making, building and analyzing a simple decision tree will be discussed. Markov modeling and Monte Carlo simulation will be introduced. All participants must bring a Windows laptop computer with a copy of TreeAge Pro Suite installed and running. You will be provided download and installation instructions when you pre-register for the course. All participants will receive a cd-rom at the training. Level: Advanced.
*Prerequisite:Introduction to Modeling.This course is suitable for those who have are familiar with the various modeling methods.
S. García Martí
HEALTH TECHNOLOGY ASSESSMENT(Presented in Portuguese with simultaneous Spanish interpretation) Room: Don Diego 4 Faculty: Carisi Anne Polanczyk, MD, PhD, Associate Professor of Medicine, Cardiology Division, Federal University of Rio Grande do Sul, Porto Alegre, RS and National Institute for Health Technology Assessment, CNPq/Brazil
Course Description: Health technology assessment (HTA) is the systematic evaluation of properties, effects and/or impacts of health care technology. Throughout the process of introducing a new technology, evaluating its effectiveness, approving its addition to the market and related decision-making, important ethical, clinical and economic issues need to be addressed. This course will discuss current processes used globally to introduce a new technology and the agencies that perform these processes. It will include a review of the various methods used to evaluate safety, efficacy, and technology adoption and diffusion, with emphasis on how to conduct HTA using real-world evidence. Faculty will address some of the issues facing current HTA processes such as their impact on the social and economic environment, the need for best practices, and the need for better cooperation among stakeholders. Level: Introductory/Intermediate.This course is designed for those with some experience in pharmacoeconomics
C. A. Polanczyk
UTILITY MEASURES (Presented in Spanish) Room: Don Diego 3 Faculty: Rafael Alfonso, MD, MSc, Research Associate, School of Pharmacy, Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle, WA, USA & Bogota, Colombia
Course Description: Utility measurement is a method of determining an individual’s preference for a certain outcome represented by a quantitative score (utility). During this course, methods for measuring preference-based outcomes like the standard gamble, time trade-off, and visual analogue scale will be demonstrated. Additionally, utility-based instruments (EQ-5D, HUI, QWQ, SF-36) will be briefly discussed. Utility measurement however is not only about mastering these techniques; it is about using them in such a way that health care decision-makers can apply the results, for instance in cost per QALY-analyses. For this purpose, one needs to be aware of shortcomings of the available utility measures and potential solutions. Furthermore one should be aware of the decision-making context and the way results are interpreted. To equip participants with expertise in the field of utility measurement, the most important issues will be discussed: for instance we will consider potential insensitivity of generic instruments for particular disease specific problems, and discuss to what extent adaptation of generic or disease-specific quality of life instruments may offer a solution. Also the issue of “whose values count: patient values or values from the general public?” will be discussed. Finally we turn to the interpretation in the context of resource allocation. Level: Intermediate. This course is for those with some experience with quality-of-life measures in health economic evaluation.
EXTRACTING COST DATA FOR ECONOMIC ANALYSIS IN LATIN AMERICA (Presented in Spanish) Room: Don Americo Faculty: Ximena Burbano-Levy, MD, Project Director, Florida International University, School of Integrated Sciences and Humanity, Miami, FL, USA & Bogotá, Colombia; Nelson Alvis Guzmán, MD, MSc, PhD, Faculty of the Economic Sciences Department and Director of the Health Economics Research Group, Cartagena University, Cartagena, Colombia; Heidy Alexandra Cáceres R., MD, MSc, Market Access Manager, Biopas Laboratories, Bogotá, Colombia
Course Description: This course will focus on practical aspects of cost development for pharmacoeconomic studies. The objective is to help the participant bridge the gap between understanding pharmacoeconomic theory and the practice of developing cost estimates. Factors to consider when costing pharmacoeconomic analyses, such as perspective, data sources, data classification systems, developing resource use profiles, obtaining unit costs, and making cost adjustments will be presented. Examples of issues encountered when identifying and extracting cost data will be discussed. Level: Intermediate.This course is designed for those with some experience with pharmacoeconomic analysis.
N. Alvis Guzman
H. A. Cáceres
PATIENT REGISTRIES(Presented in Spanish) Room: Don Genero Faculty: Manuel De La Llata Romero, MD , Director General of Highly Specialized Regional Hospitals, Mexico City, Mexico; Guillermo Melendez, MD, MSc, Scientific Coordinator, Nutrition Nestlé Fund, Mexican Foundation for Health, Mexico City, Mexico; Carlos Martínez Sanchez, MD, President, Mexican Society of Cardiology, Mexico City, Mexico; Jose Antonio Magaña Serrano, MD, Chief of Health Education Division, Cardiology Hospital, National Medical Center XXI Century, Mexican Institute of Social Security, Mexico City, Mexico
Course Description: This course is designed to provide an overview of patient registries and their applications in identifying “real world” clinical, safety, and patient-perspective issues. The pros and cons of registry data compared to other “real world” and clinical trial data collection will be presented. How registry information can be used to support other health economics /outcomes research initiatives and health care decision making will be addressed. Registry strategy, design, operations and measures of program success will be discussed. In addition, regulatory trends and requirements will be examined. Level: Introductory. This course is designed for those with little experience with patient registries