Overview of Current Risk Benefit Methods, Definition of Ideal Criteria of Risk Benefit Methodologies, and Discussion of Possible Alternatives
Co-Chairs: Jeff J. Guo, BPharm, PhD & Kara L. Suter
Goal: publication in a peer-reviewed journal
OBJECTIVE
The overall objective of the paper is to critique current quantitative methods of risk benefit analysis and based on the findings of this critique; define what criteria/characteristics would make up an ideal method of quantifying risk benefit. The paper could conclude with a discussion of what alternatives may be on the horizon that have more of the “ideal” criteria we’ve defined or perhaps call for the need to develop new methodologies.
SECTION ONE: CRITIQUE OF CURRENT QUANTITATIVE METHODS
In this section, writers will identify and review the literature so that the following key points can be summarized about each quantitative method of risk benefit analysis currently in use:
- Description of Method (could include history of development if applicable)
- How Method is Currently Being Used
- Strengths of Method
- Weaknesses/Limitations of Method
The following quantitative methods, originally identified by Dr. Jeff Guo for an earlier paper idea are a good starting point for what methods exist.
- Number needed to treat (NNT)
- Number needed to harm (NNH)
- Quality-adjusted life year (QALY)
- Cost-of-illness (COI)
- Willingness-to-pay
- Probabilistic simulation of benefit-risk assessment
- risk benefit plane
- benefit less risk
- multi-criteria decision analysis
- minimum clinical effectiveness
SECTION TWO: DEFINING IDEAL CHARACTERISTICS OF QUANTITATIVE METHOD
In this section, writers will synthesize what the trade-offs are of existing methods (strengths versus weaknesses) of risk benefit and answer the question, in an ideal world, what characteristics would a risk benefit metric/measure/method have? Each characteristic will be defined and discussed.
SECTION THREE: DISCUSSION OF FUTURE OF QUANTITIAVE MEASURES AND NEED TO DEVELOP ALTERNATIVE METHODOLOGIES
In this section, writers will discuss whether further development of existing methodologies could be improved to include more of the ideal characteristics identified or whether a new, alternative may be necessary.
*If we find a new alternative may be necessary, would be a good follow-up project/paper for the group.*
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