Standardizing Definition of terms:
The following definitions were proposed by the Issues and Methods
Definitions Working Group. A manuscript has recently been accepted for publication in
Value In Health.
Medication Compliance and Persistence: Terminology and Definitions
Medication Compliance (Synonym: Adherence) is the extent to
which a patient acts in accordance with the prescribed interval
and dose of and dosing regime. The unit of measure for compliance
is administered doses per defined period of time, reported as a
proportion (%) of prescribed doses (D) taken at the prescribed
time interval (T) as measured by the period of time, i.e., % of
TD, measured by percentage.
Medication Persistence is the accumulation of time from
initiation to discontinuation of therapy. Measured by time metric.
ISPOR Good Research Practices: A Checklist of Medication Compliance and Persistence Studies Using Retrospective Databases