Program

    Monday, May 19th
7:00am-8:00am Medication Compliance Special Interest Group (SIG) Working Group Chair Breakfast Meeting (Private)

Quality of Life Special Interest Group (SIG) Working Group Chair Breakfast Meeting (Private)

Managed Care_PBM Special Interest Group (SIG) Working Group Chair Breakfast (Private)
 

7:00am-8:00am Breakfast with the Experts
 
  • Gerry Oster PhD, Vice President, PAI, Brookline, MA, USA
  • Michael Drummond PhD, Director, Centre for Health Economics, University of York, York, UK
  • David Miller PhD, Head-Health Outcomes, GlaxoSmithKline, Greenford, Middlesex, UK
  • M. Haim Erder PhD, Director-Health Economics & Epidemiology, Amgen, Inc., Thousand Oaks, CA, USA
8:00am-8:15am Welcome
  Kevin Schulman MD, MBA, ISPOR 8th Annual International Meeting Program Chair and Director, Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA

ISPOR Service Awards Presentation
Presented by: Peter Davey MD, FRCP, 2002-2003 ISPOR President and Head of Pharmacoeconomics, University of Dundee, Dundee, Scotland, UK

Presidential Address
Peter Davey MD, FRCP, 2002-2003 ISPOR President and Head of Pharmacoeconomics, University of Dundee, Dundee, Scotland, United Kingdom
 

8:15am-9:45am First Plenary Session
  NEW MEDICAL TECHNOLOGY: WHAT WILL IT COST? CAN WE AFFORD IT?

Moderator: Kevin Schulman MD, MBA, ISPOR 8th Annual International Meeting Program Chair and Director, Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA

Speaker: Frank Sloan PhD, Alexander McMahon Professor of Health Policy and Management, Fuqua School of Business, Duke University, Durham, NC, USA

Speaker: Mark Pauly PhD, Bendheim Professor; Professor of Health Care Systems, Business and Public Policy, Insurance and Risk Management, and Economics, The Wharton School, University of Pennsylvania, Philadelphia, PA, USA

Speaker: Henry J. Aaron PhD, Senior Fellow, Economic Studies, The Brookings Institution, Washington, DC, USA
9:45am-10:30am Break, Exhibits, Contributed Poster Presentations – Session I
  Break sponsored by JeSTARx
10:30am-12:00pm Contributed Podium Presentations
 

CARDIOVASCULAR DISEASE I

  Moderator: Joseph Capelleri PhD, MPH, Associate Director, Pfizer Inc, Groton, CT, USA

CV1

PATTERNS AND RISK FACTORS FOR NON-COMPLIANCE WITH HMG-COA INHIBITORS IN A MANAGED CARE POPULATION
Yu AP, Nichol MB, University of Southern California, Los Angeles, CA, USA

CV2

 

CHOLESTEROL GOAL ATTAINMENT IN PATIENTS WITH DIABETES: EVIDENCE FROM MANAGED CARE
Menzin J1, Brown J1, Friedman M1, Saperia G2, Graham LA3, 1Boston Health Economics, Inc, Waltham, MA, USA; 2Fallon Clinic/Saint Vincent Hospital, Worcester, MA, USA; 3Pfizer, New York, NY, USA

CV3

 

INFLUENCE OF DIABETES AND BASELINE ST-SEGMENT CHANGE STATUS ON THE COST-EFFECTIVENESS OF AN EARLY INVASIVE VS. CONSERVATIVE STRATEGY FOR THE TREATMENT OF ACUTE CORONARY SYNDROMES: APPLICATION OF A NET-BENEFIT REGRESSION APPROACH TO DATA FROM THE TACTICS-TIMI 18 TRIAL
Mahoney EM1, Chu H1, Jurkovitz CT1, Cannon CP2, Alexander C3, Nag S3, Weintraub WS1, 1Emory University School of Medicine, Atlanta, GA, USA; 2Brigham and Women's Hospital/Harvard University, Boston, MA, USA; 3Merck & Co, Inc, West Point, PA, USA

CV4

EFFECTIVENESS OF AMLODIPINE VS VALSARTAN UPON BLOOD PRESSURE CHANGE AND CONTROL AMONG HYPERTENSIVE ADULTS
McLaughlin T1, Tang SS2, Roberts C3, Battleman DS2, 1NDCHealth, Phoenix, AZ, USA; 2Pfizer, Inc, New York, NY, USA; 3NDCHealth, Yardley, PA, USA
  METHODOLOGY ISSUES
  Moderator: Karen Rascati RPh, PhD, Professor, University of Texas, College of Pharmacy, Austin, TX, USA

MD1

AN ECONOMETRIC APPROACH TO GENERATING POPULATION COST ESTIMATES FOR EVENT-TIME DATA: AN EXAMPLE USING RENAL TRANSPLANT GRAFT FAILURE DATA
Irish W1, Sherrill B2, 1RTI Health Solutions, Durham, NC, USA; 2RTI Health Solutions, Research Triangle Park, NC, USA

MD2

COMPARISON OF PATIENT SELF-REPORTED HEALTHCARE RESOURCE UTILIZATION TO ELECTRONIC RECORD DATA: LESSONS LEARNED FROM A STUDY OF HERPES ZOSTER PATIENTS
Itzler R1, Choo P2, Bauer M3, Bulotsky M1, Canning C4, Coplan P1, Nikas A1, Pellissier J1, 1Merck Research Laboratories, Blue Bell, PA, USA; 2Channing Laboratory, Boston, MA, USA; 3Vanguard Medical Associates, Watertown, MA, USA; 4Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA

MD3

 

 

THE IMPACT OF REQUIRING A FIXED PERIOD OF ELIGIBILITY IN ECONOMIC AND EPIDEMIOLOGICAL STUDIES THAT UTILIZE LONGITUDINAL DATA
Eaton SC1, McQuay LJ1, Clark DW2, Paul JE1, Hauber AB3, 1RTI Health Solutions, Research Triangle Park, NC, USA; 2GlaxoSmithKline, Inc, Research Triangle Park, NC, USA; 3RTI Health Solutions, Hatboro, PA, USA

MD4

AUTOMATING ECONOMIC ANALYSIS OF CO-MEDICATION USE IN CLINICAL TRIALS
Waldeck R1, Kawabata H2, Yuan Y2, 1Bristol-Myers Squibb, Wallingford, CT, USA; 2Bristol-Myers Squibb, Princeton, NJ, USA
  QUALITY OF LIFE/PATIENT PREFERENCES
  Moderator: Daniel Polsky PhD, Research Associate Professor, University of Pennsylvania, Philadelphia, PA, USA
QL1 RELATIONSHIP BETWEEN QUALITY OF LIFE, UTILITY, AND WILLINGNESS TO PAY IN PATIENTS WITH DIABETES
Powers C, Suh DC, Shin H, Rutgers University, Piscataway, NJ, USA
QL2

 

CLINICAL IMPROVEMENT AND RESPONSIVENESS OF PHYSICAL FUNCTION MEASURES: TREATMENT WITH CTLA4IG (BMS-188667) IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS
Li T, Williams GR, L'Italien G, Kawabata H, Nuamah I, Bristol-Myers Squibb, Princeton, NJ, USA
QL3

 

DIABETIC PATIENTS’ WILLINGNESS TO PAY FOR DIABETES EDUCATION BY PHARMACISTS: VALIDITY OF CONTINGENT VALUATION METHOD
Suh DC, Powers C, Shin H, Rutgers University, Piscataway, NJ, USA
QL4

 

SMOKING STATUS AND HEALTH-RELATED QUALITY OF LIFE (HRQOL): FINDINGS FROM THE BEHAVIORAL RISK FACTOR SURVEILLANCE SYSTEM (BRFSS) DATA
Mody RR, Smith MJ, West Virginia University, Morgantown, WV, USA
  PEDIATRICS
  Moderator: Mark Nuijten MD, MBA, Director of European Business Development, MEDTAP International, Molenpad, The Netherlands
PD1 SUICIDE ATTEMPTS BY ADOLESCENTS: HOSPITAL RESOURCE USE AND COSTS
O'Brien JA, Pitoniak-Morse CA, Caro J, Caro Research Institute, Concord, MA, USA
PD2 A RANDOMIZED CONTROLLED TRIAL OF A DRUG USE REVIEW INTERVENTION FOR ANTIBIOTICS MEDICATIONS FOR OTITIS MEDIA
Lee Y, Christensen DB, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
PD3

 

RELIABILITY AND VALIDITY OF KINDL CHILDREN GENERIC HEALTH-RELATED QUALITY OF LIFE QUESTIONNAIRE IN AN ASIAN SCHOOL-BASED SAMPLE
Hwee Lin W, Shu Chuen L, National University of Singapore, Singapore, Republic of Singapore
PD4

 

LONGITUDINAL EXAMINATION OF OUTCOMES ASSOCIATED WITH BOTULINUM TOXIN USE IN CHILDREN WITH CEREBRAL PALSY
Balkrishnan R, Camacho F, Smith BP, Koman AL, Wake Forest University School of Medicine, Winston-Salem, NC, USA
12:00pm-1:00pm Lunch, Exhibits, Contributed Poster Presentations - Session I
  Lunch sponsored by Caro Research
1:00pm-2:00pm Issues Panels
  Defining a cost-effectiveness acceptability criterion: Is one needed? How should it be identified?

Chair: A. Mark Fendrick MD, Associate Professor, University of Michigan Medical Center, Ann Arbor, MI, USA

Panelists: Marc Botteman MA, Executive Director, Abt Associates, HERCULES, Bethesda, MD, USA;  Andrew Briggs PhD, Health Economics Research Centre, University of Oxford, Institute of Health Sciences, Oxford UK; Rich Hirth PhD, Associate Professor, University of Michigan, School of Public Health, Ann Arbor, MI, USA

This issues panel will discuss the value and appropriateness of defining CEA thresholds for health care decisionmakers. The same benchmarks - with no real basis in science - continue to be cited decade after decade despite a lack of strong evidence that they are a key element in the decisionmaking process. Moreover, these oft-noted thresholds have not been updated for factors such as inflation, income growth, or changes in the capability of medicine or societal preferences. Continued adherence to outdated thresholds threatens the credibility of economic evaluations.

FDA's frequently asked questions for outcomes research during the drug approval process and how the industry should prepare to answer them

Chair: Richard Willke PhD, Senior Director, Global Health Economics, Pharmacia, Peapack, NJ, USA

Panelists: Laurie Burke RPh, FDA, Rockville, MD, USA; Kati Copley-Merriman MS,MBA, Senior Director/Site Leader, Global Outcomes Research, Pfizer,Inc,Ann Arbor, MI, USA; Patrick Marquis MD, MBA, Managing Director, MAPI Values, Boston, MA, USA; Jane A. Scott PhD, Social Science Analyst, Study Endpoints and Label Development (SEALD), US FDA, Rockville, MD, USA

This issues panel will conduct a mock end-of-phase II meeting at which several health outcomes endpoints will be proposed for labeling. Answers to both company and FDA questions will be presented.

Combination Products: The Role of Outcomes Research

Chairs:
Greg de Lissovoy PhD, MPH, Vice President, MEDTAP International, Bethesda, MD, USA and Seema Sonnad PhD, Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA

Panelists: Mark Kramer, Director, Office of Combination Products United States Food & Drug Administration, Rockville, MD, USA; Paul Marshall, Director, Health Economics, Cordis Corporation, Division of Johnson & Johnson, Warren, NJ, USA.

Drug-device combination products are increasingly important in health care. This session will explore application of health economics and outcomes research methods that are often quite distinct for drugs and devices to combination products

Bayesian Statistics: Barriers to Acceptance by Decision-Makers

Chair: Bryan Luce PhD, MBA, Senior Research Leader & CEO, MEDTAP International, Bethesda, MD, USA

Panelists: Anthony O’Hagan BBc, PhD, Professor of Statistics, University of Sheffield, Sheffield, UK; Steven Sheingold PhD, Senior Economist, Health Care Financing Administration, Baltimore, MD, USA

This issue panel reviews the Bayesian statistical approach to developing and presenting evidence for decision makers, the benefits of and barriers to such an approach
 

2:00pm-5:00pm ISPOR Student Council Mock Interview Session
2:00pm-2:15pm Break
Break Sponsored by JeSTARx
2:15pm-3:15pm Contributed Workshops – Session I
  Quality of Life/Patient-Reported Outcomes/Valuation Issues

WW1

CAN THE SF-36 BE USED IN CALCULATING QALYS?
Lee TA1, Hollingworth W2, Kind P3, 1Hines VA Hospital, Hines, IL, USA; 2University of Washington, Seattle, WA, USA; 3University of York, York, UK

WW17

COMBINING QUALITATIVE AND QUANTITATIVE TECHNIQUES IN THE DEVELOPMENT OF PATIENT-REPORTED OUTCOME MEASURES
Fehnel SE, McLeod LD, Williams VSL, RTI Health Solutions, Research Triangle Park, NC, USA.
  Healthcare Policy Issues

WW3

 

MEDICARE REIMBURSEMENT TRENDS AND THEIR IMPACT ON PRODUCT PLANNING
Simison D, Robinson S, PharmAnalysis Group, Inc., Alexandria, VA, USA
  Outcomes Research – Practical Application Issues

WW4

 

RISK MANAGEMENT PRIMER AND INTRODUCTION TO NEW INFORMATION SOURCES AND TOOLS
Morris LS, IMS Health, Plymouth Meeting, PA, USA

WW5

 

PRACTICAL DECISION ANALYSIS FOR THE DECISION MAKER
Brixner DI1, Malone DC2, Avey SG3, 1University of Utah, Salt Lake City, UT, USA; 2University of Arizona, Tucson, AZ, USA; 3Foundation of Managed Care Pharmacy, Alexandria, VA, USA

WW6

 

INCORPORATING HEALTH OUTCOMES INTO THE DRUG DEVELOPMENT PROCESS: OPTIMIZING YOUR HEALTH OUTCOMES STRATEGY
Brod M1, Swindle R2, 1The Brod Group, Mill Valley, CA, USA; 2Eli Lilly and Company, Indianapolis, IN, USA
  Cost Study Issues

WW7

 

IN SEARCH OF AN UNBIASED ESTIMATE OF TREATMENT EFFECT USING OBSERVATIONAL DATA: A COMPARISON OF PROPENSITY SCORING AND HECKMAN TWO STAGE SAMPLE SELECTION MODELS.
Ganguly R1, Martin BC1, Dorfman JH1, Rizzo JA2, 1University of Georgia, Athens, GA, USA; 2Cornell University, Ithaca,
NY, USA

WW8

PHARMACOGENOMICS AND ECONOMIC ANALYSIS
Bala MV1, Zarkin GA2, Mauskopf JA2, 1Centocor, Inc, Malvern, PA, USA; 2RTI Health Solutions, Research Triangle Park, NC, USA
3:15pm-3:30pm Break
  Break Sponsored by JeSTARx
3:30pm-4:30pm Contributed Workshops – Session II
  Quality of Life/Patient-Reported Outcomes/Valuation Issues

WW9

VALUING EQ-5D HEALTH STATES: METHODS AND RESULTS
de Charro F1, Kind P2, 1Erasmus University, Rotterdam, Netherlands; 2University of York, York, UK

WW10

UNDERSTANDING TREATMENT SATISFACTION: THE WHO, WHAT, WHERE, WHEN AND HOW OF INCORPORATING TS AS A CONCEPTUALLY SOUND AND VALID PRO
Brod M1, Skovlund SE2, 1The Brod Group, Mill Valley, CA, USA; 2Novo Nordisk, Bagsvaerd, Copenhagen, Denmark

WW11

NEEDS-BASED QUALITY OF LIFE ASSESSMENT
McKenna SP, Doward LC, Galen Research, Manchester, UK
  Healthcare Policy Issues

WW12

STANDARDIZING COST-EFFECTIVENESS ANALYSIS: THE CHOICE PROJECT IN THE WORLD HEALTH ORGANIZATION
Tan-Torres Edejer T, Baltussen R, Lauer J, Hutubessy R, World Health Organization, Geneva, Switzerland
  Outcomes Research – Practical Application Issues

WW13

RISK MANAGEMENT: IMPLICATIONS FOR FORMULARY DECISION-MAKING FROM RISK-BENEFIT TO COST-EFFECTIVENESS
Shaya FT1, Mullins CD1, Wong W2, 1University of Maryland School of Pharmacy, Baltimore, MD, USA; 2CareFirst BlueCross BlueShield, Baltimore, MD, USA

WW14

 

ACTIVITY-BASED COSTING: APPLICATIONS AND IMPLEMENTATION
Schmier JK, Halpern MT, Fernandez JE, Exponent, Alexandria, VA, USA
  Cost Study Issues

WW15

BUDGETARY IMPACT ANALYSES FOR STATE MEDICAID PROGRAMS: ONE MODEL OR FIFTY?
Menzin J1, Harnett J2, 1Boston Health Economics, Inc, Waltham, MA, USA; 2Pfizer, Inc, New York, NY, USA

WW16

USE OF HEALTH INSURANCE CLAIMS DATA TO BUILD CLINICAL PATHWAYS MODELS FOR PHARMACOECONOMIC
EVALUATION

Huse D, McGarry LJ, Innovus Research, Inc, Medford, MA, USA
4:30pm-5:00pm Break
  Break Sponsored by JeSTARx
5:00pm-6:00pm ISPOR Forums
  Student Forum
 

Interviewing for a Career in Pharmacoeconomics and Outcomes Research: A discussion on interviewing for careers in academia, consulting, and the pharmaceutical industry with experts in their respective fields.
 

  Speakers: Kem Krueger PharmD, PhD, Auburn University, Auburn, AL, USA; Karen Rascati RPh, PhD, University of Texas, Austin, TX, USA; Bryan Luce PhD, MBA, MEDTAP International, Bethesda, MD, USA; Rob Hauser PharmD, Institute for Advanced Studies in Aging & Geriatric Medicine, Bethesda, MD, USA; Ron Ozminkowski PhD, The MEDSTAT Group, Inc, Ann Arbor, MI, USA; Christopher Castin, Morristown, PA, USA; Sandeep Duttagupta PhD, Pfizer Inc., New York, NY, USA; Mohammed Omar PhD, RPh, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
 
  Medication Compliance Special Interest Group Forum
5:00 – 5:05 Moderator: Joyce Cramer BS, Medication Compliance SIG Chair and Associate Research Scientist, Yale University School of Medicine, Department of Psychiatry, Westhaven, CT, USA
5:05 – 5:15 Speaker: Michael B. Nichol PhD, Analyses Standards Working Group Chair and Department of Pharmaceutical Economics & Policy Chair, University of Southern California, Los Angeles, CA, USA
5:15 – 5:25 Speaker: Peter K. Wong PhD, MBA, RPh, Issues & Methods Definitions Working Group Chair and Vice President, Clinical Effectiveness & PI, Good Samaritan Hospital, Dayton, OH, USA
The medication compliance and treatment persistence definitions established by this Issues & Methods Definitions Working Group and the related issues and methods they are working on will be presented.
5:25 – 5:35 Speaker: Jasmanda H. Wu PhD, MPH, MBA Bibliography Working Group Chair and Epidemiologist, Aventis Pharmaceuticals, Somerset, NJ, USA
A summary of report citations related to medication compliance, treatment persistence and implications for health outcomes compiled by the Bibliography Working Group, will be presented.
5:35 – 5:45 Speaker: Andrea Adamus, PhD, Education Working Group Co-Chair and Research Specialist, Department of Pharmacoeconomics, Division of Pharmacy, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA
The plans for educating providers and users of health outcomes data on the implications of medication compliance and treatment persistence issues developed by the Education Working Group will be presented.
5:45 – 5:55 Speaker: Tamas Andras Koncz PhD, Economics of Compliance Working Group Chair and Health Economist, AARDEX Ltd., Zug, Switzerland

The progress and plans toward developing definitions of costs related to medication compliance and treatment persistence by the Economics of Compliance Working Group will be presented.
5:55 – 6:00 Moderator: Joyce Cramer BS, Medication Compliance SIG Chair and Associate Research Scientist, Yale University School of Medicine, Department of Psychiatry, Westhaven, CT, USA

Closing Remarks
 
  Medication Compliance Sig: Issues & methods definitions working group meeting
6:00-7:00 Speaker: Peter K. Wong PhD, MBA, RPh, Issues & Methods Definitions Working Group Chair and Vice President, Clinical Effectiveness & PI, Good Samaritan Hospital, Dayton, OH, USA
 
  Quality of Life Special Interest Group Forum
5:00 – 5:05 Moderator: Pennifer Erickson PhD, Quality of Life SIG Chair and Co-founder, Online Guide to Quality of Life Assessment (OLGA), State College, PA, USA
During this forum the five QOL Working Groups will present their goals, accomplishments, activities and future plans.
5:05-5:15 Speaker: Eva Lydick PhD, Population Health Working Group Chair and Director of Epidemiology, AstraZeneca, Wilmington, DE, USA
An update on the WHO information exchange between methodologists and policy makers within the context of QALY measures of population health will be presented.
5:15-5:25 Speaker: Diane Wild MSc, Cross-Cultural & Translational Adaptation Working Group Chair and Partner, Oxford Outcomes Headington, Oxford, UK
The Cross-Cultural & Translational Adaptation Working Group drafted a best practices checklist on the use of outcome measures in different cultures and across languages. Issues regarding the way that measures are developed, translated, and culturally adapted will be presented.
5:25-5:35 Speaker: Michael Friedman PhD, Analysis & Interpretation Working Group Chair and Director of Biostatistics, Purdue Pharma, Stamford, CT, USA
The Analysis & Interpretation Working Group is focusing on clinical significance of QOL measures and other patient-related outcomes and will present their recent literature review on methodological articles.
5:35-5:45 Speaker: Margaret Rothman PhD, Concepts & Definitions Working Group Chair and Executive Director of Health Economics, Johnson & Johnson Pharmaceutical Research & Development, Raritan, NJ, USA
The Concepts & Definitions Working Group’s monograph on Health Related Quality of Life (HRQOL), soon to be published in the ISPOR Health Care Cost, Quality, Outcomes: ISPOR Book of Terms, will be presented.
5:45-5:55 Speaker: Pennifer Erickson PhD (for John Brazier PhD), Values & Valuation Working Group and Professor of Health Economics, ScHARR, University of Sheffield, Sheffield, UK
The Values & Valuation Working Group plans to create a Web-based digest of articles on issues related to the valuation of QOL measures will be presented.
5:55-6:00 Moderator: Pennifer Erickson PhD, Quality of Life SIG Chair and Co-founder, Online Guide to Quality of Life Assessment (OLGA), State College, PA, USA
Closing Remarks
 
  Quality of Life Special Interest Group Breakout Sessions
6:00pm–7:00 pm These sessions allow Annual Meeting attendees to speak informally with the Chair and Core group members of a specific QoL SIG working group
 
Population Health Working Group Breakout Session 
Cross-Cultural & Translational Adaptation Working Group Session
Values & Valuation Working Group Breakout Session
Concepts & Definitions Working Group Breakout Session
Analysis & Interpretation Working Group Breakout Session

6:00pm-8:00pm Exhibitors’ Open House Reception & Contributed Poster Presentations (Session I)
Reception sponsored by MEDTAP International
7:00pm-8:00pm ISPOR Learning Outcomes Task Force Core Group Meeting (Private)
7:00pm-8:00pm ISPOR Internet Education Steering Group Meeting (Private)
7:30pm-9:00pm Value in Health Editorial Advisory Board Dinner (Private)
   

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