Sixth Annual International Meeting

HERQuLES™
Health Economic Research and
Quality of Life Evaluation Services

AACT's HERQuLES is a leader in collecting and analyzing data on the use of health care products and services and on their clinical, economic, quality of life and satisfaction outcomes. Our approach — widely respected for its integrity — has helped a broad array of organizations to demonstrate the value of their products in a very competitive global marketplace. To assist our clients in optimizing the market success of their products, our experienced team offers these services:

• Retrospective Analysis and Economic Modeling
• Quality of Life Assessment and Tool Development
• Patient Registries and Other Prospective Studies
• Strategy / Pricing Support and Complementary Services

For more information, please contact:
Chris L. Pashos, Ph.D.
Vice President and Executive Director of HERQuLES
Bethesda, MD and Cambridge, MA
Voice: 1 617 520 2935
Fax: 1 617 868 2221
E-mail: chris_pashos@abtassoc.com

Adis International

Adis International, a Wolters Kluwer International Health and Science Company, is a leading provider of integrated business intelligence solutions, global strategic communications services and clinical publications for the pharmaceutical and healthcare industries. Adis provides access to the latest pharmaceutical intelligence from around the world and 'best evidence' support in the areas of drug and disease management from its highly specialized Business Intelligence, Healthcare Communication, and Medical and Scientific Publishing divisions. Established in the 1960s to publish independently evaluated information on new drug compounds, Adis launched its first international review journal, Drugs, in 1971. Since then the company has grown to over 500 employees in thirteen countries, supplying evaluation and analysis in all therapeutic areas. In addition to Drugs, other well known titles include PharmacoEconomics, Disease Management and Healthcomes and PharmacoEconomics & Outcomes News.

Blackwell Science

Visit Blackwell Science, the proud publisher of the journal Value in Health, at the 2001 ISPOR meeting. Stop by our booth to review the latest issues of top medical books and journals. Book titles on display will include a new publication by Barton Cobert, Pharmacovigilence A to Z. Visit our booth or online at www.blackwellscience.com.

The Analytica Group is a research consultancy that provides timely delivery of market-driven Health Economics and Outcomes Research. Based in Manhattan, the group is currently conducting research in the United States, Canada, Europe, Latin America, and Asia. The multi-national and multi-disciplinary staff includes physicians, epidemiologists, economists, engineers, pharmaceutical research scientists, and biostatisticians. The Analytica Group is currently engaged with eight of the top ten pharmaceutical companies in the world.

Assist Technologies, Inc.
3295 N. Drinkwater Blvd., Ste. 1
Scottsdale, AZ 85251
Tel. (480) 874-9400
Fax (480) 874-9414
Email: theron@assisttouch.com
Web: www.assisttouch.com

Assist Technologies, Inc. (AT) provides a complete outsourcing service to collect and manage patient survey data as part of a clinical trial or outcomes study. This service is based on replacing traditional paper surveys with easy to use touch-screens. AT provides both software and hardware and services to support our clients' protocol. AT will train the sites, provide support, receive data transmissions from the sites and store the data in a secure repository. AT will provide monthly monitoring reports to spot any compliance or quality problems.

BioMedCom Consultants inc. was established in 1996 to fill a special need within the health care community; we specialize in the planning and transmission of health economic and health outcomes research information. Our mission is to advance the ethical and effective communication of research information to the health care community, to policy- and decision-makers, and to the general population. We accomplish this in a respectful, creative and humanistic working milieu. Our Services: strategic communication planning; research reports & manuscripts; formulary submission syntheses; scientific & lay summaries; literature reviews; abstracts and presentations; newsletter and periodical articles; scientific editorial review; training in document preparation and management. Our Competitive Advantage: Research scientists as writers and editors; experienced in research communications; work based on international standards; academic and industry experience; objective external perspective; adherence to timelines; rationalized and competitive rates; documents in English and French. Telephone: 514-745-0915 Facsimile: 514-745-0916 Website: www.biomedcom.org Address: 3767 Thimens Boulevard, Suite 226, Montreal, Quebec H4R 1W4 Canada

3600 Market Street Philadelphia, PA 19104 Phone: 215-387-9401 Fax: 215-387-9406 Contact: Greg Hess, M.D., M.B.A

CareScience's LifeCycle Decision System™ provides tools and services that shorten the drug development cycle and improve development yield. CareScience offerings include a suite of Internet-based data analysis and workflow management tools, consulting services, customized research and strategic development support. These tools and services are aimed at the specialized drug development needs of pharmaceutical industry clinicians, product managers, market strategists, health economists, and outcomes researchers.

Clinical Therapeutics®

Clinical Therapeutics®, now in its 23rd year, offers rapid, peer-reviewed publication of clinical studies, review articles, and pharmacoeconomics/outcomes research. Manuscripts are usually published within 6 to 8 weeks of acceptance and in-depth peer review usually requires 3-4 weeks.

For the past 8 years, CT's specialty section, Pharmaceutical Economics & Health Policy, has focused on the publication of economic/health outcomes/QOL research, policy/contemporary issues, as well as review articles, brief reports & commentaries.

Clinical Therapeutics® is indexed by more than 30 of the world's leading databases, including MEDLINE/Index Medicus, EMBASE, Current Contents, and International Pharmaceutical Abstracts. (Latest JCR Impact Factor = 1.955)

Clinical Therapeutics® is published by Excerpta Medica U.S., whose parent organization, Elsevier Science, is the world's largest publisher of medical and scientific journals with more than 1200 titles such as The Lancet, The American Journal of Medicine, Journal of the American College of Cardiology, and FDC Reports ("The Pink Sheets").

The Disease Map® Company

The Disease Map® Company (www.diseasemaps.com) creates customized Web-based information products for internal and external marketing. Disease Maps® provide rapid support for product acceptance using peer-reviewed outcomes, economics, and policy information. Each Disease Map® assembles, structures and integrates outcomes data focused on disease and product-specific topics and presents them in a user-friendly and easily accessible intranet or extranet site. The Maps are easily updated to support marketing campaigns as commercial strategies develop and mature. The Disease Map® Company integrates original and corporate outcomes content designed to target formulary committee, physician and health plan customers.

For more information contact:
Linda Davidson Ray Duke Clinical Research Institute         PO Box 17969 Durham, NC 27715	Tel: 919-668-8765 Fax: 919-668-7251 linda.davidson.ray@duke.edu

HEED is the world's leading International database of economic evaluations in health care, used by health economists in the pharmaceutical industry, academia, health care organizations and consultancies. HEED comprises 21,500 evaluations in an easy to read structured format covering the period 1967 to current date. HEED covers several types of economic evaluation including cost effectiveness analysis, cost consequence analysis, cost minimization analysis, cost benefit analysis and cost utility analysis. Cost of illness and cost analysis studies are also included. HEED is updated monthly and is available on CD-ROM or via the Internet.

provides the healthcare industry with state of the art outcomes research services, including health economics, epidemiology and clinical experience studies. For nearly 20 years ICSL Healthcare Research has conducted customized research solutions to document effectiveness, safety, and cost-effectiveness of pharmaceutical products, and to educate the medical community about the clinical and economic dimensions of many diseases. Our professional staff of economists, epidemiologists, biostatisticians, project managers and software developers provide the scientific and operational skills required to implement a wide range of research methodologies. ICSL Healthcare Research conducts turnkey research projects, including study design, protocol writing, data management, statistical analysis, publication and presentation. We provide services throughout the product development cycle, from early modeling studies designed to aid investment decisions at Phases I and II to comprehensive post-marketing clinical and economic research programs. To date ICSL Healthcare Research has studied more than 140,000 patients in its registries and other field studies. ICSL Healthcare Research is now the outcomes research division of Innovative Clinical Solutions Ltd., one of the largest clinical research organizations in the US. For more information about ICSL Healthcare Research please contact us at 800-762-3419 or visit our web page at www.icsltd.net/icsl_hr/.

IMR, an AdvancePCS Company, is a leading provider of integrated clinical, epidemiological, and drug therapy information solutions that assist pharmaceutical manufacturers, health plans, and institutions with critical decisions affecting patient care. Working in partnership with our pharmaceutical and plan sponsor clients we provide cutting edge healthcare services, research analysis, and decision support tools used to improve patient health, safety and quality of life. AdvancePCS is the nation's largest independent provider of health improvement services, touching the lives of more than 75 million health plan members and managing more than $20 billion annually in prescription drug spending.

Ingenix Pharmaceutical Services has over 10 years experience in pharmacoeconomic, epidemiology, and outcomes research. Ingenix researchers use large databases to conduct cost-of-illness, treatment pattern analysis, cost-minimization and treatment outcome analyses.

Contact information:
phone:	Jon Clouse (952)833-8338 or Mike Nelson (952)833-6585
email:	jon.clouse@ingenixps.com or michael.nelson@ingenixps.com
internet:	www.ingenixps.com or www.epidemiology.com

INNOVUS is a leading health economic and quality-of-life research organization, providing services to international pharmaceutical companies since 1988. Our highly skilled and dedicated group of specialists includes internationally renowned experts Drs. Michael Drummond, George Torrance, and Milton Weinstein. Together with a network of prominent investigators, academics and strategic alliances, we've created an unparalleled, service-oriented and client-focused team.

INNOVUS has offices in Toronto and Boston, and London. Our international presence ensures that we are well-equipped to meet the challenging research needs in the pharmaceutical marketplace and provides an excellent base for coordinating multinational health economic programs. Research services:

• Modeling studies
• Retrospective database analyses
• Prospective research
• Survey design & administration
• Quality of life research
• Strategic planning
• Research transfer

Institute of Empirical Health Economics Am Ziegelfeld 28 D-51399 Burscheid, Germany Telephone: +49-(0)2174/7151-0 Telefax: +49-(0)2174/7151-98 E-mail: instfeg@t-online.de Internet: http://www.instfeg.de

The Institute of Empirical Health Economics provides analytical services to health care authorities, to international pharmaceutical companies, to sickness funds and health care insurers and to clinical research programmes.

Our services are:

• Studies and evaluations in hospitals and the GP area
• Decision-tree-analyses and Markov models
• Outcomes research studies
• Consultancy for cost reduction
• SOP's
• Benchmarking
• Moderation and joint meetings with health care providers and payers

The Adelphi Group provides leading-edge expertise in strategic marketing, market insight and understanding, outcomes research and message-driven communications. Adelphi's products include the Disease Specific Programmes, an unrivalled source of European and US disease-specific information to support study design and model assumptions.

As part of Adelphi, Mapi Values works to deliver health and economic outcomes services to a wide range of clients including most of the major pharmaceutical companies worldwide.

Our team brings a wide range of experience, knowledge and expertise in health economics, patient satisfaction, health-related quality of life, marketing research, digital-media communication solutions and project management to our clients and their projects. With offices in the UK, France, Belgium and the USA, we are able to conduct truly international projects. The Adelphi Group takes a holistic view in supporting the development of your product and has the insight to ensure that our Outcomes Research projects provide the scientific evidence to support your marketing messages in a seamless, effective and pragmatic manner.

McKessonHBOC Patient Registries
A unit of McKessonHBOC Pharmaceutical Partners Group
7564 Standish Place, Suite 108
Rockville, MD 20855, USA
Telephone: (301) 217-9660
Fax: (301) 217-0923
Internet: www.mckhboc.com
Email: ed.dougherty@mbs-mckhboc.com
Contact Person: Edward J. Dougherty, Sr. Vice-President, Patient Registries

McKessonHBOC Patient Registries offers an integrated team of clinicians, IT experts and experienced project managers to design and implement Phase IV Clinical Registries.

• Strategic consulting to help achieve clinical, marketing and educational objectives
• Thought-leader development
• Protocol design
• Site identification, recruiting, initiation and auditing
• Web-based data capture
• Automated data transfer and reporting
• Adverse event reporting and management
• Strict compliance with regulatory guidelines on data quality and respondent confidentiality

MEDSTAT's Research and Policy group provides custom database development, outcomes research, and other health services research to the federal government and to the pharmaceutical industry and other private funders. MEDSTAT's work in outcomes research encompasses prospective and retrospective observational studies and intervention design and evaluation.

MEDSTAT also licenses large, longitudinal healthcare databases to pharmaceutical companies and other clients for use in conducting their own research. MarketScan® Research Databases link inpatient, outpatient, pharmaceutical, enrollment, and benefit plan design data for millions of covered lives.

Mental Health Outcomes, Inc.

Mental Health Outcomes, Inc. (MHO) is a national leader in outcomes measurement systems created specifically for psychiatric programs.

MHO provides PsychScope™ — a proprietary, clinically-based national behavioral health database that can be purchased as PsychStat™, a Quarterly Audit Report; PsychProfiler™ Customized Studies; and PsychPlus™ Value-Added Marketing Partnerships. PsychScope serves pharmaceutical companies with CNS portfolios.

For more information, please contact Ed Repp, Director Market Development or Keith Whitlock, Director Market Development at 800/266-4440 or at erepp@horc.com or kwhitlock@horc.com.

MetaWorks Inc. is the Pharmaceutical industry's leading provider of Evidence-based Medical Information (EBMI) solutions. Our systematic reviews, literature monitoring, meta-analysis and our state-of-the-art MetaMap software provide essential clinical data for any pharmacoeconomomic or outcomes research project. With a highly trained scientific staff, innovative services and technologies, a steadfast commitment to scientific excellence and customer service, MetaWorks is uniquely qualified to deliver the fast, clear, accurate answers the pharmaceutical industry needs most. To see how our EBMI solutions fit your needs, visit us on the web at www.metaworksinc.com. For project inquiries, please contact: Matthew Bush Senior Product Manager 781-395-0700 or at bushm@metawork.com

Milliman & Robertson, Inc.

Today's Problems for Pharmaceutical Companies

• How to demonstrate value to payers
• The need to speak insurers' financial language
• Zero-based Rx budgeting
• The prescription drug silo
• Low credibility

Today's Solution

• Answers from M&R:
  actuarial/clinical/economic/strategic

For 50 years, the leading actuarial consultants to the insurance industry

2394 E. Camelback Road Phoenix, AZ 85016

NDCHealth assists its customers in providing quality care at greater efficiency and lower cost by providing end-to-end solutions (point of service systems, intelligent network and information management services) to pharmaceutical manufacturers, pharmacies, hospitals, physicians and payers.

NDCHealth supports over 90% of the nation's pharmacies, more than 20% of the nation's hospitals, over 180,000 physicians, over 1,000 payers representing over 4,000 payer plans and more than 75% of all pharmaceutical manufacturers by delivering over 250 products and services.

NDCHealth's Outcomes Research

The cost of pharmaceutical products in relation to the benefits they provide is an important issue for patients, providers, and third-party payers. Through Outcomes Research, pharmaceutical manufacturers have the means to demonstrate the value of drug interventions. This rapidly growing category of healthcare research assesses the broad impact of your product/intervention from the economic, clinical and humanistic standpoint. Outcomes Research at NDCHealth's Pharmaceutical Services business unit offers a powerful combination of industry understanding and Outcomes Research expertise to offer comprehensive strategic planning and studies tailored to your requirements. To provide real value for your product/intervention, we integrate all three aspects of Outcomes Research:

• Clinical Outcomes measure medical care associated with a disease or treatment of a disease.
• Humanistic Outcomes assess quality of life, functional status and patient satisfaction.
• Economic Outcomes determine the costs associated with treating a disease.

If you would like more information on NDCHealth's Outcomes Research, please call (800) 778-6711 or visit our web site: www.ndchealth.com.

The Office of Health Policy and Clinical Outcomes

The Office of Health Policy and Clinical Outcomes, one of the few academically based outcomes research centers nationally, has achieved a reputation of quality and excellence. As consultants to academia and industry, we design and conduct outcomes studies (including pharmacoeconomic studies) and performance evaluations. Our accomplishments in the fields of migraine, diabetes, cardiology and senior health care exemplify the depth and breadth of the expertise of the Office staff. The Office furthers our mission of fostering quality and cost-effective healthcare by providing our clients with a wide array of educational programs and services. We develop and implement innovative programs for both academia and industry. We serve as a liaison between managed care and the pharmaceutical industry — organizing and moderating proactive and reactive advisory boards, critical to current issues or assumptions. We provide access to decision-makers and thought leaders. We are skilled in assessment, content, and evaluation. We are a facilitator of change — linking our clients' business needs with initiatives to improve healthcare.

Maximizing performance in the marketplace. Omnicare Clinical Research's dedicated Peri-Approval Unit makes it happen. Using a customized approach, we integrate clinical research, innovative data capture technology, medical communications and outcomes capabilities to achieve your trial objectives. Simply put, you get product positioning for full market potential —which means we make sure you get your share. All phases of clinical development. All over the world. 1-800-290-5766 • 484-679-2400 www.OmnicareCR.com 630 Allendale Road, King of Prussia, PA 19604

Ovation Research Group is an independent health economics and outcomes research and consulting firm headquartered outside Chicago. Ovation combines pioneering experience in health economics with unique insights into achieving cost-effectiveness in various healthcare settings. Ovation's experience in designing and implementing outcomes research strategies includes:

• Prospective clinical/ economic humanistic trials (Phase II-IV)
• Prospective naturalistic studies (Phase IIIB/IV)
• Retrospective database studies
• Economic analyses:
  - Decision modeling
  - Cost of illness
• Prospective studies in managed care
• Patient and product registries

PharMetrics offers the next step in the evolution of market insight: patient-level information. Using fully encrypted, integrated medical and pharmacy claims information, we've compiled data that can give you a unique perspective on your market. Our patient-level data includes detailed information on patient age and gender, diagnoses, resource utilization and treatment costs, concomitant therapies, co-morbid conditions, and much more.

Our database is massive — and unique:

• Over 20 million patients
• From more than 40 MCOs
• Up to four years of longitudinal data
• Representative of the managed care marketplace:
  - by age and gender
  - by managed care plan type

You can use PharMetrics' services to both expand and sharpen the picture your current data provides. Eighteen of the top 20 pharmaceutical companies rely on us for a new level of insight. Let us show you what we can do for you.

For more information, call Frank Koos at 888-515-8155 or visit us on the web at: www.pharmetrics.com

Policy Analysis Inc. (PAI) is a contract-research and consulting firm that has been serving the pharmaceutical and biotechnology industries since 1980. Located in Brookline, Massachusetts, PAI is an industry leader in the fields of outcomes research, pharmacoeconomics, quality-of-life assessment, and pharmacoepidemiology.

Premier's Healthcare Informatics

Premier's Healthcare Informatics unit is a leading provider of information and analytic services to the pharmaceutical and biotech industries. Premier has access to the nation's largest and most complete repository of hospital-based clinical and financial resource utilization data. This data is collected directly from healthcare facilities and goes through rigorous quality inspection and verification processes. Data collected include but are not limited to patients' principal and secondary procedures and diagnoses, cost of care, the drugs received during the hospital stay, treatments and dosage received by day, and physician specialty information. Using this proprietary database, Premier's Healthcare Informatics unit is able to provide custom market research and outcomes research services to address the complex and unique information needs of our clients.

Our overall mission is to provide services that support the linkage between suppliers, provider health systems and Premier in a common model that focuses on resource utilization, cost effectiveness, high quality outcomes and best practices.

Solucient powers health care decision-making. With the largest repository of health care intelligence and benchmark information, Solucient supplies pharmaceutical companies, providers, payers, consultants and employers with access to comprehensive, results-oriented information to grow their business, contain costs and deliver quality care. Solucient delivers strategic clinical, operational, financial, planning and marketing information resulting in improved health care business and clinical outcomes. Solucient's robust information helps benchmark performance across the continuum of care.

By providing access to our vast inpatient and longitudinal databases, Solucient supports clients' pharmacoeconomic research needs. With a staff of physician consultants, nurses, epidemiologists, statisticians, and information technology professionals, Solucient's experience and data collection strategies provide clients with sound databases and data projection methodologies. All of these individuals support clients and are often called upon to meet with clients when defining market research and outcomes studies. Our research focus includes:

• Outcomes measurement studies
• Patient-centered survey data collection and analysis
• Market forecasting and tracking
• Data management services
• Direct-to-Consumer marketing solutions

For further information, please contact:

Patricia Carroll
Solucient LLC
300 East Lombard Street
Baltimore, MD 21202
(800) 568-3282
pcarroll@solucient.com
www.hcia.com
www.solucient.com

We produce powerful, but extraordinarily user-friendly, software for building and analyzing decision trees, influence diagrams, and Markov models. At this year's meeting, we will be demonstrating two new products scheduled for release in June: If you are interested in using cost-effectiveness models in an interactive marketing presentation, let us show you how another of our products, DATA Interactive™, has eliminated the need to rebuild your model in Excel® or Visual Basic®. You avoid the expense, delay, and risks involved in model rebuilding, and you gain these benefits without giving up any design and artistic flexibility. http://www.treeage.com

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