POSTER PRESENTATIONS

Poster Presentation Hours
Poster Viewing: 13:00 - 19:30 Monday, 6 March 2006
 8:00 - 16:00 Tuesday, 7 March 2006
Author Presentation Hour: 17:30-18:30 Monday, 6 March 2006

HEALTH CARE USE & POLICY STUDIES

PHP1

ANALYZING PRODUCT DIFFERENTIATION IN FOUR ARGENTINEAN PHARMACEUTICAL MARKETS
Maceira DA, Center for the Study of the State and Society (CEDES), Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina

OBJECTIVE: Pharmaceutical markets are characterized by a high degree of product differentiation, where price, consumers’ income, perceived quality, and reputation interact. In addition, induced demand affects not only the impact of prices on the decision of buying a drug, but also the criteria used to prescribe it. In the Argentinean case, without patent protection, there is not a clear distinction between brand product and generics, which in turn affects the nature of competition. Marketing efforts targeting physicians (detail advertisement) consume important shares of pharmaceutical producers’ budgets. On the other hand, technical progress in chemical ingredients provides consumers and physicians with new alternatives of choice. The goal of this paper is to understand the sources of differentiation among products in four Argentinean therapeutic classes, and their effects on price elasticities. METHODS: A discrete choice model of product differentiation is used to measure demands for antidiabetics, gastroprocinetics, prostatics and quinolons, during 1988- 1995. Such demand functions start with an individual utility function, which is explained by observed prices, product characteristics, and consumers’ tastes. The econometric implementation takes the form of a nested logit model, where the first source of substitution is by chemical ingredient, followed by variables related to marketing/reputation. RESULTS: The confirmed hypothesis is that reputation builder variables are consistently significant across therapeutic classes. CONLUSIONS: In addition, the study shows a correspondence between the level of necessity of the drugs and the relative importance of chemical ingredients in the decision of consumption.
 

 

PHP2

COMPARATIVE ANALYSIS OF ADVERTISING EFFECTIVENESS BETWEEN NEW AND EARLIER ENTRANTS IN THE PHARMACEUTICAL MARKET
Kwong WJ, University of Georgia, College of Pharmacy, Athens, GA, USA

OBJECTIVE: To evaluate the presence of first-mover advantage for pharmaceutical advertising that would support the entry deterrence theory in the pharmaceutical market. METHODS: Advertising elasticities of demand for pharmaceutical products in the periods following new product entries were estimated using time and disease fixed effects estimation. One-period and two-period lag models were estimated. Logarithm of a product’s sales revenue was regressed on its own advertising expenditure, total advertising expenditure of competing products in the same market, number of competing products, number of years the product has been on market, a dummy variable indicating whether the product is a new entrant, and an interaction term between the dummy variable and the product’s own advertising expenditure. Scott-Levin Market Research Audit advertising expenditure and product sales data from Jan 1995 to Dec 2001 were used were analyzed on a quarterly basis. Products from eight therapy markets were examined: asthma, migraine, obesity, Parkinson’s disease, seizure, depression, lipid disorder, and gastric and duodenal ulcer. RESULTS: In both lag models, product sales significantly increased with a product’s own advertising expenditure, and significantly decreased with the total advertising expenditure of competing products, and the number of competing products. For existing products, advertising elasticity of demand was estimated to be 0.068% in the one-period lag model and 0.062% in the two-period lag model. Elasticity estimates for new entrants was lower at 0.046% and 0.044%, respectively. The elasticity estimates between new and existing products were not significantly different. Comparing results of the two lag models, advertising elasticity of demand depreciated at 8.7% per quarter. CONLUSIONS: Results did not find any significant first-mover advantage in the effectiveness of advertising between earlier and later entrants that would support the potential entry deterrence effect of advertising in the pharmaceutical market. These results did not support regulating pharmaceutical advertising based on anti-competitive grounds.
 

 

PHP3

STUDY ON PHARMACEUTICAL SETTING IN COMMUNITY HEALTH SERVICE
Cheng X, Fudan University, Shanghai, Shanghai, China

According to the results of cluster analysis of pharmaceutical setting of community health service, this study reveals whether it can meet the curative needs on the basis of the current condition of common diseases, frequently occurring diseases and chronic diseases. The study also analyzes its effects on drug expenditure according to different scale of pharmaceutical setting. Results of anova analysis demonstrate that the scale of pharmaceutical setting of community health service has an impact on drug expenditure to some extent. The drug expenditure per capita in the community health service group which has 200 kinds of drugs or above is higher than the group which has 100 to 200 kinds of drugs .However ,the difference between the group which has 100 to 200 kinds of drugs and the group which has less than 100 kinds of drugs is not significant.
 

 

PHP4

IDENTIFY GAPS OF EVALUATION OF ESSENTIAL MEDICINES IN CHINA
Sun X, Li Y, The Chinese Cochrane Centre, West China Hospital, Sichuan University, Chengdu, Sichuan, China

OBJECTIVE: In 2002, an evidence-based approach was initially applied to evaluate essential medicines (EM) in China. Although the performance of such an attempt was recognized, the evaluation system was considered incomplete. A study was, therefore, designed to identify the gaps. METHODS: The decision-makers and reviewers who were involved in the evaluation of EM in 2002 were convened. They were asked to answer a list of wellconstructed questions, and identify any additionally conceptualized problems throughout the process. In addition, a literature review was carried out, based on electronic search of Pubmed (1980-2004), WHO website, Australian Pharmaceutical Benefit Scheme website. RESULTS: Several key weak points of the evaluation was identified and recognized. A) Incomplete technical contents: medicines were assessed eligibility based on effectiveness and safety, and marketing prices. The drug utilization and economic feasibility were not estimated. B) Inadequate evaluation METHODS: the techniques to assess the effectiveness and safety were either outdated (e.g. quality appraisal by Jadad scale), incomplete (e.g. assessment of safety based on review of clinical trials) or inadequate (e.g. marketing prices considered, instead of costs and cost-effectiveness). C) Lack of efforts from related professionals: reviewers mostly consisted of medical specialists, pharmacologists and pharmacists. No efforts from pharmacoeconomists, pharmacoepidemiologists, and consumer and industrial representatives were contributed. D) Lack of outcome predicting and monitoring mechanism: no established outcome research methods were available, which might lead to unawareness of results of drug utilization. E) Lack of unpublished data: all the resources for evaluation came from published data, whereas unpublished data, as understood by pharmaceutical industry, were not available. This resulted in bias of selection of EM. F) Quality of evidence: the evidence, especially of traditional Chinese medicine, is too poor to be indicative for decision-making. CONLUSIONS: The evidence-based evaluation of essential medicines in China is still at its early stage.
 

 

PHP5

THE EFFECT OF DRUG POLICY ON THE ADOPTION RATES OF NEW DRUGS IN KOREAN OUTPATIENTS CARE
Choi SE, Kim JH, Health Insurance Review Agency, Seoul, South Korea

OBJECTIVE: Korea has implemented the new prescription drug policy in 2000, which separated the function of prescribing and dispensing drugs between doctors and pharmacists and purposed to improve the quality of drug use and remove the economic incentive from doctor’s prescribing behavior. The aim of this study was to understand the adoption rates of new drugs in outpatient care after the new policy, and explore the effect of the policy on the adoption rates. METHODS: Four new prescription drugs frequently prescribed in ambulatory care were selected. From 1999–2002, the National Health Insurance (NHI) claims data for prescription drugs of selected clinics was used. The dependent variable was the adoption rate defined by the period from the enlisted date of the new drug on the NHI reimbursement list to the first prescribed date by each clinic. The explanatory variables were collected from the adopter, technology, and environment characteristics including policy change. The claims data was merged with telephone survey data. Cox’s proportional hazard regression was performed to set and test the model in explaining the factors influencing on the adoption rate. RESULTS: The 1,792 observations were inputted into the model. The model showed that the new prescribing system made the adoption rate faster than before the change (HR=295.7, p<0.001) but the reimbursement restriction policy restricted the adoption rate of new drugs (hazard ratio (HR) = 0.03, p<0.001). The behavioral characteristics also influenced on the rate of adoption. Doctors who prescribe more number of drugs per claims and have higher proportion of drug costs per total medical costs were early adopters (hazard ratio 1.02, p<0.05). In addition, the innovative drugs and the drugs by multinational manufacturers were adopted earlier. CONLUSIONS: The prescribing system change accelerated the new drugs to be adopted earlier, but the reimbursement restriction policy trade off this tendency.

 

PHP7

ECONOMIC EVALUATION OF DISEASE MANAGEMENT PROGRAMS
Suh R, Uniformed Services University of the Health Sciences, Vienna, VA, USA

OBJECTIVE: To review existing methodologies for the economic evaluation of disease management (DM) programs and to identify issues and challenges facing purchasers, providers, vendors, and patients as this field continues to evolve. METHODS: A literature review of current industry standards for the economic evaluation of DM programs, to include those proposed by academicians, health plans, DM vendors, trade groups and associations, and actuaries; identification of common themes and unresolved controversies; and suggestions for next steps and further research. RESULTS: A comparison of the 7 most recent and cited publications that provide methodological recommendations for the economic evaluation of disease management programs reveal many common elements, as well as disparate approaches to dealing with known challenges and biases. Central to the differences is the need to balance practical feasibility and methodological rigor. This review identifies the key issues and considerations that remain in formulating a true industry standard for the economic evaluation of disease management programs. CONLUSIONS: Medicare’s new disease management pilot program and the Congressional Budget Office’s findings of “insufficient evidence” for the economic benefits of DM programs have both spurred on greater interest in finding valid methodologies that may be used to substantiate claims of overall cost savings and in establishing some comparability across economic evaluation studies. While some controversies remain, many organizations and individuals have put forth several proposed methodologies that seem appropriate for their target populations. Moving toward consensus in this field will need to accommodate the interests and needs of a variety of stakeholders involved in the disease management industry, and there may be a role for federal research or regulatory bodies in helping establish an industry-wide standard. Further developments in this field may have wideranging impacts as disease management continues to grow in health systems outside the United States.
 

 

PHP9

DELIVERY OF DAILY DOSES OF THE DRUGS TO HOSPITAL DEPARTMENTS AS A METHOD OF DRUG RATIONALIZATION AT THE CLINICS IN UNIVERSITY TEACHING CENTRE NOVI SAD
Sabo A, Tomic Z, Faculty of Medicine, Novi Sad, Serbia and Montenegro

OBJECTIVE: Introducing daily instead of weekly delivery of drugs and medicinal supply to hospital departments has been widely supported by Ministry of Health and Crown agency as a method for improvement of quality of drug supply and pharmacoekonomics in this field. According to published data the pharmacoeconomic consequences of this measurements could lower the drug and medicinal supply expenses for as much as 90%. In NoviSad Clinics, Serbia and Montenegro, weekly delivery of drugs and medicinal supply is stil present. Therefore, we performed a study in order to see if a change to daily dosing, together with everyday control of structure and dose of prescribed drugs by clinical pharmacologist can rationalize dug use. METHODS: Our study with daily dosing of drugs and medicinal supply started at Urological clinic, University Teaching Hospital Novi Sad, Serbia and Montenegro. At the beginning the monthly use of drugs was followed up. The drug use was calculated using ATC/DDD classification. RESULTS: According to our expectation, financial results did show substantial lowering of the drug expenses, of 36%, with antibacterilas being the most restricted drugs, followed by local anesthetics. CONLUSIONS: The new way of drug delivery, with every day follow up and corrections of the structure and amount of drugs prescribed by urologist significantly improved the safety and quality of the drugs. Constant monitoring in drug delivery enabled them to prevent potential clinically harmful interactions, to improve patients compliance together with substantial financial results, that support the new system of drug delivery.
 

 

PHP10

DEMAND NEEDS AND SUBSIDIES IN PHARMACEUTICALS: THE EXPERIENCE OF THE REMEDIAR PROGRAM IN ARGENTINA
Maceira DA, Apella IR, Barbieri E, Center for the Study of the State and Society (CEDES), Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina

OBJECTIVE: Between 2001 and 2002, as a consequence of the Argentinean economic crisis, the existent gap between potential and effective demand for pharmaceutical products increased, especially in low income households. As a result, the Ministry of Health launched the Remediar Program, consisting in the public provision of medicines among houses under the poverty line and without formal health coverage. By implementing a subsidy for pharmaceutical products, families can substitute their own purchases by free medicaments, shifting their incomes to alternative uses. Considering that Remediar acts as an indirectly subsidy for the demand of medicines through primary health care posts (CAPS), the main propose is to know the ability of the Program to reduce the gap between potential and effective demands under the poverty line, as well as its effects over welfare in terms of generated savings. METHODS: By using two Household Surveys on Expenses and Utilization at the CAPS level during 2003 and 2004, designed for this research, the paper develops a probit model, estimating the probability of accessing to free prescriptions, as a function of household incomes and socioeconomic characteristics, formal health insurance coverage levels, and the participation of each CAP into the Program. The results were compared to the data provided by the National Household Survey of Expenses and Utilization in Health developed by the Ministry of Health in 2003. RESULTS: Estimations suggest a potential redistributive effect due to the Program, by improving equity on expenditures on pharmaceuticals, which may imply a reduction of the Gini coefficient from 0.11 to 0.08. In addition, population under the first and second income quintile might reach saving of their expenses in drugs of 22.5 and 6.7 percent, respectively. CONLUSIONS: The paper shows the effectiveness of the Remediar in increasing the access to medicines of patients at the lowest income quintiles.
 

 

PHP11

DETERMINANTS OF CATASTROPHIC EXPENDITURE AND IMPOVERISHMENT OF HOUSEHOLDS IN THAILAND
Prakongsai P1, Tangcharoensathien V2, Limwattananon S3, 1International Health Policy Program, Amphoe Muang, Thailand, 2International Health Policy Program, Nonthaburi, Thailand, 3Khon Kaen University, Amphoe Muang, Khon Kaen, Thailand

OBJECTIVE: To explain variations in the magnitude of health care catastrophe and household impoverishment from out-of-pocket (OOP) payments in relation to differences in services and providers of health care during the pre- and post- universal health care coverage (UC) periods in Thailand. METHODS: Analysis of the national socio-economic surveys of household income and consumption in 2000 (N=24,747), 2002 (N=34,785) and 2004 (N=34,843). RESULTS: Households whose members being admitted to hospitals for inpatient (IP) experienced health care expenditure beyond a catastrophic level (defined as OOP payments more than 10% of total consumption) most frequently (31.0% during pre- UC period in 2000 and 15.1-14.6% during post-UC period in 2002-2004). The catastrophic incidence in households with OOP payments for out-patient (OP) without IP services was less frequent (12.0% pre-UC and 7.9-8.3% post-UC). The households paying OOP only for self medication faced the catastrophic expenditure by only 2.1% and 0.4-0.6% over the same period. Among the households at risk to health care catastrophe from IP service during the post-UC period, the catastrophic incidence varied from 32.1-27.8% for services by private hospitals, and 13.9-11.1% by provincial hospitals and 6.5-7.3% by district hospitals respectively. The variations in household impoverishment due to OOP health payments followed a similar catastrophic pattern. Paying for IP services accounted for the poverty increase by 95.6% and 84.0-71.5% of the impoverished households during pre-UC and post-UC periods, respectively. The relative increase in post-OOP impoverishment was found in 98.8-100% of those became poor from the payments to private hospitals regardless of type of health care services. CONLUSIONS: Households making OOP payments for IP services and private hospitals were most likely to face the catastrophic health care expenditure and impoverishment.
 

 

PHP12

EXPLORING THE AVAILABILITY & CHARACTERISTICS OF HEALTH CARE COST DATA ACROSS SELECTED ASIAN COUNTRIES
Bindra S1, Duttagupta S2, Chan BS3, Hongxia C4, Cheah SK5, Wei Y4, Zhong J4, Sze-Man Lai J6, Somasundaram S7, Suvarna V7, Nawawi S8, Lee HJ9, Park HJ9, Nawaz A10, Tranquilino F11, Martin N11, Ramachandran S12, Kulasingham S13, Lam KM14, Li M15, Lin S15, Chu C16, Ponprasit K17, Nganthavee W17, Pramanik A18, 1Pfizer Asia Regional Office, Hong Kong, Hong Kong, 2Pfizer Inc, New York, NY, USA, 3The Chinese University of Hong Kong, Hong Kong, China, 4Pfizer China, Beijing, China, 5Pfizer Singapore, Singapore, Singapore, 6Pfizer Hong Kong, North Point, Hong Kong, 7Pfizer India, Jogeshwari, Mumbai, India, 8Pfizer Indonesia, Jakarta, Indonesia, 9Pfizer Korea, Seoul, South Korea, 10Pfizer Pakistan, West Wharf, Karachi, Pakistan, 11Pfizer Phillipines, Makati City, Philippines, 12Pfizer, Selangor, Malaysia, 13Pfizer Malaysia, Selangur Darul, Malaysia, 14Pfizer Singapore, Gateway East, Singapore, 15Pfizer Taiwan, Tamsui, Taiwan, China, 16Pfizer Taiwan, Tamsui, China, 17Pfizer Thailand, Bangkok, Thailand, 18Pfizer Asia, Admiralty, Hong Kong

OBJECTIVE: Increasingly local and regional health care payers are requesting economic analyses for new drugs in order to effectively allocate resources in various Asia-Pacific countries. However, the availability of uniform and reliable local or regional data sources necessary to conduct such analyses is limited. In an effort to better understand the availability and characteristics of the health economic data sources from selected countries in this region, the following exercise was conducted. We collaborated with various institutions across selected Asian markets to gather relevant data to identify opportunities for economic analyses reflecting local and/or regional health care practices. METHODS: A list of commonly used health care services associated with hospitalized patients was developed from published literature. Health care institutions were approached to provide corresponding unit cost data, while keeping within respective country-specific privacy regulations. In addition, wherever available, costs from published sources were also collected. RESULTS: Indicative of the social, cultural and economic diversity of the region, health care service costs varied considerably across the selected countries. Cost for a comparable hospital bed/day in a private ward varied from as little as US$32 in Indonesia to US$72 in Pakistan. Significant differences were also seen in the cost per bed/day in a comparable ICU setting, ranging from as little US$271 in Singapore to US$1800 in Hong Kong Significant variances were also observed for cost data collected on a number of comparable inpatient and outpatient services. CONLUSIONS: While progress is being made to develop pharmacoeconomic analyses specific to health care demand in the Asia-Pacific region, the quantity and quality of available data to meet these demands are still very limited.
 

 

PHP14

EFFECTS OF USING AN AUTOMATED PRESCRIPTION FILLING SYSTEM ON PHARMACY STAFF UTILIZATION AND PRESRIPTION FILLING LABOR
Lin AC1, Huang YC1, Punches G2, Chen Y1, Qian JJ1, 1University of Cincinnati, Cincinnati, OH, USA, 2Punches Pharmacy Plus, Michigan, MI, USA

OBJECTIVE: To evaluate the effects of using an automated prescription filling system, ScriptPro 2000, on pharmacy staff utilization and prescription filling labor in an independent US pharmacy. METHODS: Self-controlled before and after the installation of the automation. Pharmacy Setting: The Punches Pharmacy Plus, an independent pharmacy located in Clare, Michigan, USA and with a daily workload of 360 prescriptions was selected as the study site in this study. Intervention: The installation of an automated prescription filling system, ScriptPro 200. Data Collections: Videotaping and work measurement techniques were used in collecting the data of before and after installation of the ScriptPro 200. Study Variables: The utilization of the pharmacy staff (pharmacists and technicians) and the labor utilized in direct and indirect prescription-filling activities, e.g., receiving order, order entry, filling, inspecting, packaging and dispensing, phone calls, inventory management, were measured and compared before and after the installation. RESULTS: With the installation of automation, the pharmacy staff was significantly reduced (?2=25.54, P<0.001) by 0.4 FTEs (Full Time Equivalence) pharmacists’ efforts were shifted to the technicians. Meanwhile, there was a statistically significant difference in term of the percentages of labor spent on various activities between the pre-installation and postinstallation of automation (?2=137.65, P<0.001). Analyses of average labor used per prescription showed that the installation of automation could save 0.22 minutes per prescription. Especially, for the counting labor per prescription, it significantly decreased from 2.63 minutes to 2.07 minutes with an average of 0.56 minutes saved (Z=-1.984, P=0.045). CONLUSIONS: The automated system, ScriptPro 200, has shown the usefulness in terms of reducing the prescription filling labor. Further research efforts should continue to assess other effects in the workload, patient counseling and medication errors and conduct the economic evaluation.
 

 

PHP15

IMPACT OF PHARMACIST’S INTERVENTIONS ON COST OF DRUG THERAPY IN INTENSIVE CARE UNIT
Saokaew S1, Maphanta S2, Thangsomboon P3, 1Naresuan University, Muang, Phayao, Thailand, 2Naresuan University, Muang, Phitsanulok, Thailand, 3Buddhachinaraj Hospital, Muang, Phitsanulok, Thailand
 

OBJECTIVE: To determine pharmacist’s interventions led to change in overall drug cost and to describe the characteristics of pharmacist’s interventions in a Thai intensive care unit. METHODS: A Prospective, standard care-controlled study design was used to compare overall drug costs of patients receiving care form patient care team including a clinical pharmacist with standard care (no pharmacist on team). All Patients admitted to the medical intensive care unit (ICU) 1 and 2 during the same period were included in the study. The outcome measures were overall drug cost and length of ICU stay. Interventions made by the pharmacist in the study group were documented. The analyses of rate of acceptance and cost saving and/or cost avoidance were also performed. RESULTS: A total of 65 patients were admitted to either ICU 1 or 2 during the 5 week- study period. The pharmacist participated in patient care and made total of 127 interventions for the ICU-1 team. Ninety-eight percent of the interventions were accepted by physicians. The difference of overall drug cost per patient between two groups was 6,982.05 THB (41,298.5 THB in study group and 48,271.55 THB in control group, p = 0.138). The average length of ICU stay for the intervention group and the control group was not significantly different (7.16 days VS 6.18 days, p=0.995). The 125 accepted interventions were evaluated for cost saving and cost avoidance. Pharmacist’s interventions yielded a total of 75,624 THB from drug cost saving and 11,301 THB from adverse drug event cost avoidance. The net cost saved and avoided from pharmacist interventions was 86,925.81 THB. Interventions involving antibiotic use accounted for the largest economic impact (75,132.18 THB). CONLUSIONS: Having a pharmacist participated in ICU patient care team can reduced overall drug cost, cost saving, and cost avoidance. The largest economic impact involved antibiotic use.
 

 

PHP16

BARRIERS TO PHARMACEUTICAL CARE IN THAILAND
Ngorsuraches S1, Li SC2, 1Prince of Songkla University, Hatyai, Songkla, Thailand, 2National University of Singapore, Singapore

OBJECTIVE: To examine barriers to pharmaceutical care in Thailand. METHODS: The study had a cross-sectional and descriptive design. Data were obtained from a survey of a random sample of 600 hospital and community pharmacists across the country. The survey was developed to measure barriers to the provision of pharmaceutical care from the hospital and community pharmacists’ perception using 5-point Likert scales (1 = ‘strongly disagree’ to 5 = ‘strongly agree’). Descriptive statistics were used for data analyses. RESULTS: The response rate was 53.2%; with hospital pharmacists comprised 78.4% of all respondents. The majority of respondents had one to five years in patient care pharmacy practice. The Cronbach alpha of study measure for the pharmacists’ perception of barriers to pharmaceutical care was 0.83. The pharmacists agreed that lack of data on the proven value of providing pharmaceutical care, lack of therapeutic knowledge and clinical problem-solving skills, and lack of role model who provides pharmaceutical care deterred them from providing pharmaceutical care. On the other hand, lack of opportunities for face-to-face encounters with patients, lack of patient demand and acceptance of pharmaceutical care, and other health care providers’ resistance did not greatly prevent them from providing pharmaceutical care. CONLUSIONS: Even though pharmaceutical care has been adopted to pharmacy practice and documented to prevent drug-related problems in Thailand for a number of years, the pharmacists still perceived that insufficient evidence supporting the value of providing pharmaceutical care existed. To remove the barriers, besides an increase in therapeutic knowledge, and clinical skills, more evidence of the proven value of providing pharmaceutical care and role models for pharmaceutical care are also needed.
 

 

PHP18

SURVEY STUDY OF PHARMACOECONOMIC RESEARCH IN THE PACIFIC ASIA REGION
Luo MP, Cifaldi M, Abbott Laboratories, Abbott Park, IL, USA

OBJECTIVE: Given the rapid economic growth and increasing rate of health care spending in the Pacific Asia (PA) area, pharmacoeconomic research (PE) has the potential to assist decision-making on pharmaceutical coverage. This study evaluated the environment and the future trend for PE in the PA region. METHODS: A comprehensive survey of pricing and reimbursement personnel from pharmaceutical industry was conducted in 15 countries in the PA area in 2004. The survey consisted of 22 structured questions and covered the following issues: health care system, PE guidelines, factors impacting pricing and reimbursement decision, importance of PE data in supporting reimbursement, submission channel for PE data and future expectations. The questionnaire was pretested for content validity. Respondents were expected to answer the survey relying on their own local knowledge and experience. RESULTS: The response rate on the survey was 87% (13 out of 15 countries). In most countries reimbursement mechanisms were reported as combination of government funding and private insurance. Over 60% of the countries had a reimbursement list for prescription drugs. Most countries indicated that drug price was determined based on reference pricing, parity pricing and pharmaceutical profitability, while reimbursement decision was primarily based on drug price, but clinical data and pharmaceutical data also had a role. At the time of the survey, one-fifth of the countries indicated that PE data were required for reimbursement and additional one-half of the countries indicated that PE data were helpful. Three-fourth of the surveyed countries expected that PE data would be required for pricing and reimbursement within 5 years. CONLUSIONS: Although there were variations with regard to the practice and potential for PE data among the surveyed PA countries, this study suggested that PE is emerging in the PA region and more countries are moving toward some formal requirement for PE evidence for pharmaceuticals.
 

 

PHP19

ANALYSIS OF PHARMACEUTICAL PRICE CHANGES IN A REGIONAL HOSPITAL SYSTEM
Kelton CM1, Guo JJ1, Rebelein RP2, Ferrand Y1, Dusing ML3, 1University of Cincinnati, Cincinnati, OH, USA, 2Vassar College, Poughkeepsie, NY, USA, 3Health Alliance, Cincinnati, OH, USA

OBJECTIVE: Drug expenditures have been rising rapidly in the United States over the past decade, with annual double-digit increases, due partly to rising utilization and partly to rising prices. Hospital expenditures on pharmaceuticals rose 11 percent between 2000 and 2001, with considerable variation across individual drug purchases. Our objectives are (1) to identify drugs with extreme transaction price changes and (2) to determine whether large swings are associated with particular manufacturers and/or therapeutic classes. METHODS: Monthly expenditure and utilization data are collected for the 2000 and 2001 calendar years for a large, six-hospital system for all regularly purchased drug products. Monthly transaction prices are derived from these data, and annual price changes are calculated from average annual transaction prices for the two years, for approximately 3000 drug products. RESULTS: 185 drugs had price swings of at least 20 percent. The largest price increases were for fentanyl citrate and albuterol with annual rises of 368 percent and 273 percent, respectively. There were 13 drugs with price increases of 100+ percent. The hospital buyer experienced the largest number of high price increases in the adrenal, penicillin, and antiretroviral-agent therapeutic classes, while the companies responsible for the highest number of price increases were Pharmacia & Upjohn, GlaxoSmithKline, Mead Johnson & Company, and UDL Laboratories. A regression of price change on company and class dummy variables reveals that only seven percent of the variation in price change can be explained by company or class affiliation. CONLUSIONS: Price changes for individual drugs can be quite substantial even over a single year. Though there is significant variation in individual drug price change (from -80 percent to over 300 percent), very little of this variation can be explained by manufacturer or therapeutic class. Drug-specific factors such as patent expiration or production issues must explain most of it.
 

 

PHP20

ANALYSIS OF THE PRESCRIPTIONS FILLING LABOR IN A MAJOR US DRUGSTORE CHAIN
Lin AC, Qian JJ, Chen Y, University of Cincinnati, Cincinnati, OH, USA

OBJECTIVE: This study was designed to quantify the staffing utilization, in terms of the time spent by pharmacy staff on various activities, and the direct and indirect prescription filling time, in an US chain drugstore. METHODS: Eight pharmacy sites of a major US drugstore chain. Data Collections: Videotaping and work measurement techniques were used to collect the data from each selected pharmacy. Each pharmacy was observed by strategically installed cameras for seven days including five weekdays and two weekends. One minute fixed interval work sampling approach was applied for reviewing the videotapes. Study Variables: The utilization of the pharmacy staff and the time spent in direct and indirect prescription-filling activities, such as: receiving, order entry, filling, inspecting, packaging and dispensing phone calls, inventory management, were measured and compared through the work sampling process. RESULTS: Totally, 166,703 minutes during 56-day study period at eight sites were observed, among which 1,087.9 hours (65,276 minutes) for the pharmacists and the other 1,609.5 hours (101,427 minutes) for technicians. The results indicated an overall of 10.02 minutes (including 7.88 minutes for direct filling activities and 2.15 minutes for indirect filling activities) were spent by each prescription. The ratio of pharmacist verse technician in direct filling time is 1:1.52, but 1:1.65 in indirect filling time. CONLUSIONS: This study illustrated the time spent on various activities related to prescription filling by the pharmacy staff in an US drugstores chain and provides the micro-view of labor consumed for each prescription filling. This study enables the managers of pharmacy to utilize the pharmacy staff with optimal staffing arrangements. Further efforts should be put into the study of potential factors affecting the efficiency of pharmacy.
 

 

PHP21

THE EFFECTS OF AUTOMATED PRESCRIPTION FILLING SYSTEM ON THE INVOLVEMENT OF PHARMACY STAFF IN PRESCRIPTION FILLING ACTIVITIES
Lin AC, Huang S, Qian JJ, Chen Y, Ma XQ, University of Cincinnati, Cincinnati, OH, USA

OBJECTIVE: This study was to examine if the use of an automated prescription filling system would affect the pharmacy staff involvement in prescription filling activities in a major US chain drugstore. METHODS: Eight pharmacy sites were selected from one major US drugstore chain. Data Collections: Videotaping, work measurement, and telephone recording techniques were used for data collection. Cameras were strategically installed, collecting data for a continuous seven days in each sample site. One minute fixed interval work sampling approach was applied in reviewing the videotapes. Study Variables: The time spent in non-judgmental prescription filling activities by pharmacy staff, including drop off, order entry, filling packing, and storing by pharmacists and technicians were also observed. Data Analysis: Mann-Whitney test was applied and all the statistical analyses were performed using the software SPSS. RESULTS: Among the eight selected pharmacies, three pharmacies were equipped with Pharmacy 2000 and Baker Cell and five did not have automation technologies. The time spent by pharmacists on non-judgmental activities per prescription in pharmacies with and without automation was 1.33 ± 0.99 and 2.06 ± 0.50 minutes, respectively (Z=-1.043, P=0.297). The time spent by technicians was 4.14 ± 1.11 and 2.78 ± 0.33 minutes (Z=-1.64, P=0.101). The ratio of time spent on non-judgmental activities by pharmacists and technicians in the pharmacies with and without automation were 1:3.11 and 1:1.35, respectively. Moreover, there was an average of 0.12 minutes spent by pharmacists on patient counseling per prescription in pharmacies with automation, which was about twelve times more than pharmacies without automation. CONLUSIONS: It indicates: 1) more non-judgmental prescription filling activities were performed by technicians due to the working shift by the automation, and 2) pharmacy staffs increase direct contacts with customers at the pharmacies featuring an automatic prescription filling system.
 

 

PHP22

THE EFFECTS OF TELEPHONE CALLS ON PRESCRIPTION FILLING EFFICIENCY IN A DRUGSTORE CHAIN
Lin AC, Waston W, Chen Y, Qian JJ, University of Cincinnati, Cincinnati, OH, USA

OBJECTIVE: This study was to quantify the occurrence of telephone calls, and to examine the effects of those telephone calls on prescription filling efficiency in a major US drugstore chain. METHODS: Four pharmacies (A, B, C, and D) of one major US chain drugstore were selected for this study. Data Collections: Videotaping, work measurement, and telephone recording and reviewing techniques were used. Telephone calls were automatically captured and digitalized by the computer system. Study Variables: The study variables include the number of prescriptions filled per hour, direct prescription filling time (DRxFT), and daily frequency of phone call. Data Analysis: Each phone call was reviewed and categorized. One minute fixed interval work sampling approach was applied for reviewing the videotapes. RESULTS: The daily frequency of phone calls in pharmacies, A, B, C, and D were 230.14±77.81, 116.14±66.46, 160.86±136.26, and 309.43±157.48, respectively (F=3.706, P=0.025). The corresponding estimated number of prescriptions filled per hour and DRxFT were 5.94±1.21 and 7.01±1.73 for pharmacy A, 6.93±3.62 and 6.48±1.95 for pharmacy B, 6.48±1.37 and 7.07±1.50 for pharmacy C, 5.25±1.29 and 8.52±1.79 for pharmacy D, respectively. It was found the more daily phone calls the pharmacy had, the less number of prescriptions were filled per hour, thus, taking longer to fill one prescription; however, the correlation between frequency of daily phone calls and number of prescriptions filled per hour were not found to be statistically significant (r=-0.052, P=0.793), as well as the correlation between the daily frequency of phone calls and DRxFT (r=0.183, P=0.352). CONLUSIONS: Although the findings were not statistically significance, a positive correlation was found between the DRxFT and daily frequency of phone calls. More frequent phone calls were associated with longer DRxFT and lower hourly prescription throughput rate. Reducing the frequency of incoming daily phone calls could improve the efficiency of pharmacy operation.
 

 

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DEVELOPING A QUANTITATIVE SCORING SYSTEM FOR ADVERSE DRUG REACTION ASSESSMENT USING GENETIC ALGORITHM
Koh Y, Yap CW, Li SC, National University of Singapore, Singapore

OBJECTIVE: To improve the scoring system of a newly developed ADR algorithm to measure the probability of ADR causality. METHOD: Several ADR cases obtained from Pharmacoviligance Unit at Ministry of Health with known causality probability values were used as reference points for the development of the scoring system. Based on a review of ADR reports with definite causality assessment, several rules were developed to define all possible combinations of criteria for ‘Definite’ ADR cases and some combinations for ‘Probable’ ADR cases. These parameters were used to determine the new scoring system with the help of genetic algorithm. Testing of the new scoring system was performed on 37 ‘Definite’ ADR cases. In addition, sensitivity and specificity analysis were performed to allow a comparison of performance between our algorithm and the algorithm used by ADRAC. RESULTS: When this new scoring system developed by using genetic algorithm was applied to the 37 ‘Definite’ ADR reports, 83.8% were identified as ‘Definite’ compared to 21.6% by guidelines from ADRAC. Our new algorithm gave a sensitivity of 83.8% and specificity of 71.0% (versus 21.6% and 98.4% respectively for ADRAC). Hence, our algorithm had more cases being classified correctly. CONLUSIONS: The refining of the scoring system to reflect a quantitative scale has helped make this algorithm more sensitive and increased its useful index, especially when used by clinicians, regulatory agencies or drug companies to generate ADR alert signals. Using a quantitative method of assessing causality also mean that rare ADRs and new ADRs can be detected since a quantitative score can give more precisely the degree of ADR causality.
 

 

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MODULAR STUDY FOR MEDICAL SUPPLIES IN SUDDEN PUBLIC HEALTH EVENTS
lulu Z1, Yuan L1, Guoquan R2, 1Second Military Medical University, Shanghai, China, 2General Logistics, PLA, Beijing, China

OBJECTIVE: Nowadays, how to prevent and handle sudden public health events has become a popular talk in public health administration. Medical supplies in sudden public health events play a more important role in the study of sudden public health events handling. Fine medical supplies is not only benefit to handle sudden public health events quickly, but has good economic effect. Based on this analysis, we put forward a modularization method for medical supplies in sudden public health events. METHODS: We gathered proceeding related material, and analysed the characteristic of medicine demand and consumption laws. We also studied disease composition of different sudden public health events, severe degree of disease and different parameters of treatment for all kinds of diseases. In accordance with the principle of modularization, adopting system analysis and statistics methods, we designed all kinds of basic modules and the combination methods for these modules under every sudden public health event. First, to divide medical supplies into a certain number of basic modules, then combine these basic modules into different aggregates which compose the medical supplies modules. RESULTS: According to the results of the data collection, we used modularization method and cluster analysis to ascertain the scope of atreatment of basic module. On the basis of these studies, we formed the standard of variety and quantity of basic modules. Then we used modularization combination method to complete the combination of basic modules under different sudden public health events. CONLUSIONS: When sudden public health events happen, we can work out a supply plan quickly according to kind and severe degree ensuring the timely handling of these events. Additionally, modularization for medical supplies provides a new method to medicine reserve of preventing sudden public health events for us, which must be helpful to save money and resources.
 

 

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HOW DO SURVEY RESPONDENTS INTERPRET AND UTILIZE SYMBOLS USED IN HEALTH VALUATION STUDIES?
Wee HL1, Li SC2, Zhang XH2, Xie F2, Luo N3, Cheung YB4, Machin D5, Fong KY1, Thumboo J1, 1Singapore General Hospital,Singapore, 2National University of Singapore, Singapore, Singapore, 3QualityMetric Inc, Lincoln, RI, USA, 4London School of Hygiene & Tropical Medicine, London, UK, 5National Cancer Centre Singapore, Singapore

OBJECTIVE: Symbols have been used in health valuation studies to aid respondents in valuing health states. As it is unclear if symbols are culturally appropriate and useful in Asians, we studied their usefulness in differentiating various severity levels of a health state in a multi-ethnic, urban Asian population. METHODS: In in-depth interviews with adult Chinese and Indian Singaporeans (selected to represent various ages/ educational levels) conducted in English, Chinese or Tamil, respondents were shown a health state with 6 levels (HUI3 vision), each linked with a symbol, with increasing severity implied by increasing number of sides in each symbol. Respondents were asked if symbols were: 1) useful in differentiating severity of each level (measured using both dichotomous and 0-10 VAS scales); 2)offensive, and 3)to assess seven alternative symbol sets. RESULTS: Of 46 subjects (54% Chinese, 54% female, median age: 42 years), 23 (50%) understood that symbols represented various ranked health levels. However, only 11 of 46 subjects (24%) felt symbols were useful in differentiating severity of each level. Reported usefulness of symbols was low (median VAS score (IQR): 3.0 (0.0, 6.0), 12 (26%) subjects giving a score above 5). No subject felt symbols were offensive. When asked to assess alternative symbol sets, 14 (30%) respondents expressed no preference, 4 (9%) preferred numbers and 28 (61%) preferred alternative sets. Among these 28 subjects, squares of increasing size were preferred by 35%, followed by squares of the same size in different shades of grey (26%). CONLUSIONS: Although symbols were culturally acceptable, less than one quarter of Chinese in Indian subjects found them useful in differentiating various severity levels, suggesting that symbols are useful only for a subgroup of subjects. Selection of the ideal symbol set for use in health valuation would be difficult, given the preference for a wide variety of symbol sets.
 

 

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WHAT FACTORS INFLUENCE THE RANKING OF IMPORTANCE OF HEALTH DOMAINS? AN EXPLORATORY STUDY AMONG CHINESE AND INDIAN SINGAPOREANS
Xie F1, Li SC1, Wee HL2, Zhang XH1, Luo N3, Cheung YB4, Machin D5, Fong KY2, Thumboo J2, 1National University of Singapore, Singapore, 2Singapore General Hospital, Singapore, 3QualityMetric Inc, Lincoln, RI, USA, 4London School of Hygiene & Tropical Medicine, London, UK, 5National Cancer Centre Singapore, Singapore

OBJECTIVE: The relative importance of various health domains may vary among individuals. We sought to identify factors influencing the ranking of health domains in a multi-ethnic, urban Asian population. METHODS: In in-depth interviews with adult Chinese and Indian Singaporeans (selected to represent various ages/educational levels) conducted in English, Chinese or Tamil, respondents were asked to rank EQ-5D domains (mobility, selfcare, usual activities, pain/discomfort, anxiety/depression) from most to least important. Mann-Whitney U tests/Chi-square tests and logistic regression models were used to determine the influence of ethnicity, age, gender, education, and presence of chronic medical conditions on ranking for mobility or self-care as the most important domain (as ² 5 respondents ranked each of the remaining domains as most important). RESULTS: Of 46 respondents (54% Chinese, 54% female, median age: 42 years), 20 (44%) respondents ranked mobility and 16 (35%) ranked self-care as most important respectively. Respondents ranking mobility as most important were more likely to be older (49.1 vs 38.6 years, p=0.008) or ethnic Indians (70% vs 30%, p=0.005). Both variables were statistically significant in the logistic regression model (OR=1.06, 95%CI=1.00-1.11, p=0.023, and OR=7.09, 95%CI=1.67-30.03, p=0.008, respectively). Respondents ranking self-care as most important were more likely to be younger (37.6 vs 46.4 years, p=0.027). This variable was close to attaining statistical significance in the logistic regression model (OR=0.96, 95%CI=0.91-1.00, p=0.067). CONLUSIONS: This exploratory study suggests that ethnicity and age may influence the ranking of important health domains in a multiethnic urban Asian population in Singapore.
 

 

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THE IMPACT OF TALKING ABOUT DEATH ON HEALTH STATE VALUATION: A STUDY AMONG CHINESE AND INDIAN SINGAPOREANS
Wee HL1, Li SC2, Zhang XH2, Xie F2, Nan L3, Cheung YB4, Machin D5, Fong KY1, Thumboo J1, 1Singapore General Hospital, Singapore, 2National University of Singapore, Singapore, 3QualityMetric Inc, Lincoln, RI, USA, 4London School of Hygiene & Tropical Medicine, London, UK, 5National Cancer Centre Singapore, Singapore

OBJECTIVE: Cultural differences in willingness to discuss death may influence participation rates, accuracy of responses and cross-cultural comparability in health valuation studies. We therefore characterized perceptions and comfort in discussing death in a multiethnic, urban Asian population. METHODS: In in-depth interviews with adult Chinese and Indian Singaporeans (selected to represent various ages/ educational levels) conducted in English, Chinese or Tamil, subjects rated their ease in discussing death (EID) using a 0-10 visual analogue scale (VAS). Subjects also reported, using the same scale: 1) religiosity; 2) acceptability of 8 descriptors for death (e.g. passed away, sudden death, immediate death); and 3) preference for “pits” versus “all-worst”. Finally, subjects valued 3 hypothetical health states using 0-100 VAS followed by time trade-off (TTO). The influences of various factors on EID were compared using Mann-Whitney tests. Correlations between EID and health utilities were evaluated using Spearman rank correlation. RESULTS: Among 46 subjects (54% Chinese, 54% female, median age: 42 years), median self-reported religiosity was significantly lower for Chinese (5.0 (0.0, 7.0)) compared to Indians (7.0 (5.0, 10.0), p=0.004). Subjects were generally comfortable in discussing death (median (IQR): 8.0 (7.0 to 10.0)). Neither sociodemographic factors nor religiosity influenced subjects’ comfort level. In relation to descriptors for death, both Chinese and Indian subjects felt “passed away” (median (IQR): 8.0 (7.0, 10.0)) was more acceptable than “sudden death” (5.0 (3.0, 7.0)) or “immediate death” (5.0 (2.0, 7.0)). Subjects clearly preferred “all-worst” (median (IQR): 8.0 (6.0, 9.3)) to “pits” (5.0 (0.8, 8.0)). Correlations between EID and health utility score were generally weak (range –0.263 to 0.386 (VAS) and –0.283 to 0.162 (TTO)). CONLUSIONS: Chinese and Indian Singaporeans were generally comfortable in discussing death. The poor correlation between EID and health utility scores suggests that the latter are unlikely to be influenced by willingness to discuss death.
 

 

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DOES RANKING OF HEALTH DOMAINS INFLUENCE HEALTH UTILITIES? AN EXPLORATORY STUDY AMONG CHINESE AND INDIAN SINGAPOREANS
Xie F1, Li SC1, Wee HL2, Zhang XH1, Luo N3, Cheung YB4, Machin D5, Fong KY2, Thumboo J2, 1National University of Singapore, Singapore, Singapore, 2Singapore General Hospital, Singapore, Singapore, 3QualityMetric Inc, Lincoln, RI, USA, 4London School of Hygiene & Tropical Medicine, London, United Kingdom, 5National Cancer Centre Singapore, Singapore, Singapore

OBJECTIVE: We hypothesized that an individual would likely express a lower utility for a health state (HS) in which the health domain that s/he values is impaired, and explored this in a multi-ethnic, urban Asian population. METHODS: In in-depth interviews with adult Chinese and Indian Singaporeans conducted in English, Chinese or Tamil, respondents were asked to; (i) sort and rank 3 EQ-5D HS (A, B and C) on 0-100 visual analogue scale (VAS), and (ii) rank 5 EQ-5D domains from most to least important. Analysis was performed for mobility and self-care domains as few (²5) respondents ranked other domains as most important. We hypothesized that among subjects selecting 1)mobility: adjusted VAS scores would be lowest for HS-B (greatest mobility impairment) and highest for HS-A (least impairment); 2)self-care: adjusted VAS scores would be lowest for HS-C (greatest self-care impairment) and highest for HS-A (least impairment). We performed separate multiple linear regression (MLR) with VAS scores as the dependent variable and importance ranking (IR) as independent variables with adjustment for age, ethnicity, education and presence of chronic medical conditions. RESULTS: Of 46 respondents (54% Chinese, 54% female, median age: 42 years), 20 (44%) ranked mobility and 16 (35%) ranked selfcare as most important respectively. MLR coefficients (95% CI) for HS-A, -B and -C were: 0.8 (-11.5 to 13.1), -0.6 (-10.5, 9.3), -11.3 (-24.8 to 2.2) for mobility and 8.0 (-3.3 to 19.4), -5.5 (-14.7, 3.7), 7.1 (-5.9, 20.1) for self-care, reaching clinical significance (of 5 points) in 4 instances but were not statistically significant. In addition, the hypothesized trends were not observed. CONLUSIONS: In this exploratory study, the influence of IR on utility scores was at times clinically important, though not statistically significant. This suggests that IR may influence health utility scores, an association which needs to be tested in larger studies.
 

 

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THE VALUE PROPOSITION OF OUTPATIENT TOWARDS OUTPATIENT SERVICE.
Sooksriwong CO, Mahidol University, Bangkok, Thailand, Vijitmakthong A, King Chulalongkorn Memorial Hospital, Bangkok, Thailand

OBJECTIVE: The purpose of this study was to assess the out-patient’s value proposition of outpatient service by importance-performance rating technique. The results are expected to help in providing better services and increase patient satisfaction. METHODS: The civil servant patient group, which contributed major hospital incomes was selected to be the sample. The interviewing questionnaire was used for data collection from 358 out-patients receiving outpatient service during April and May 2004 at King Chulalongkorn Memorial Hospital. The questionnaire included important and performance assessment, general information and factors affecting the patient’s decision in selecting hospital. RESULTS: Most of the patients (64.5%) were female, 26.54% were between 45-54 years old (average 44.88 years), 61.5% held Bachelor degree. Most of them spent 1-2 hours in traveling to hospital, but they were mostly satisfied in travel time. 29.6% were new patients who visited the OPD at the first time. Among the old patient group, the average OPD visit times were 3.44 times per year. The top three high value and high performance areas, which were hospital’s strong points, were “medical service by physician”, “pharmacy service”, and “providing service by gently and friendly officers”. Three important services with high importance and low performance level which the hospital should concentrate on improving were “having guarantee waiting time in each service center”, “adequate car park”, and “clean and good hygiene restroom.” Factors affecting their decisions were “modern technology equipment”, “confidence in doctor and officer ability” and “government hospital”. Comparison of the value proposition between groups of patients were provided. CONLUSIONS: The hospital should promote its strong areas and improve its services rated as high importance and low performance in order to increase the patients’ satisfaction.
 

 

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MEASUREMENT AND VALUATION OF HEALTH STATUS EQ-5D WITH TIME TRADE-OFF IN SOUTH KOREA
Jo MW1, Yun SC2, Hwang IA1, Lee SI1, 1University of Ulsan College of Medicine, Seoul, South Korea, 2Asian Medical Center, Seoul, South Korea

 

   

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